小鼠对卡介苗迟发型超敏反应的品系差异及其遗传控制
Strain difference of delayed-type hypersensitivity to BCG and its genetic control in mice.
作者信息
Nakamura R M, Tokunaga T
出版信息
Infect Immun. 1978 Dec;22(3):657-64. doi: 10.1128/iai.22.3.657-664.1978.
Delayed-type hypersensitivity to BCG was remarkably different in two inbred strains of mice, SWM/Ms and C3H/He, when measured by the spleen index, the disappearance of peritoneal macrophage, or the footpad reaction. High responsiveness in the SWM/Ms strain appeared to be dominant over low responsiveness in the C3H/He strain. Results of the footpad reaction test if F1, F2, and backcross hybrids of these two strains of mice suggested that the delayed-type hypersensitivity was mainly controlled by a gene which was transmitted under Mendel's laws and was possibly non-H-2 linked. The spleen cells and their nylon wool nonadherent fraction from BCG-infected C3H/He mice were not reactive to purified protein derivative in vitro, whereas both the spleen cells and the nylon wool nonadherent fraction from BCG-infected SWM/Ms mice reacted well to purified protein derivative. Possible mechanisms of the different responses in the delayed-type hypersensitivity to BCG were discussed.
当通过脾脏指数、腹腔巨噬细胞消失情况或足垫反应来测量时，两种近交系小鼠SWM/Ms和C3H/He对卡介苗的迟发型超敏反应存在显著差异。SWM/Ms品系的高反应性似乎对C3H/He品系的低反应性具有显性作用。这两种品系小鼠的F1、F2和回交杂种的足垫反应试验结果表明，迟发型超敏反应主要受一个基因控制，该基因按照孟德尔定律遗传，并且可能与H-2基因不连锁。卡介苗感染的C3H/He小鼠的脾细胞及其尼龙毛非黏附部分在体外对纯化蛋白衍生物无反应，而卡介苗感染的SWM/Ms小鼠的脾细胞和尼龙毛非黏附部分对纯化蛋白衍生物反应良好。文中讨论了对卡介苗迟发型超敏反应中不同反应的可能机制。
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