低反应性小鼠对牛分枝杆菌卡介苗迟发型超敏反应中抑制性T细胞的诱导。
Induction of suppressor T cells in delayed-type hypersensitivity to Mycobacterium bovis BCG in low-responder mice.
作者信息
Nakamura R M, Tokunaga T
出版信息
Infect Immun. 1980 May;28(2):331-5. doi: 10.1128/iai.28.2.331-335.1980.
Abstract
The induction of delayed-type hypersensitivity to Mycobacterium bovis BCG was specifically inhibited by suppressor T cells in C3H/He, a strain of mice which is a low responder to BCG. The existence of these suppressor cells was confirmed by an adoptive transfer of spleen cells of BCG-injected mice into cyclophosphamide-treated recipients. The suppressor cells appeared in the spleens of the mice 2 to 7 days after intravenous BCG injection. They were sensitive to anti-theta serum and complement and did not adhere to Sephadex G-10. A pretreatment of the mice with cyclophosphamide eliminated the suppression of delayed-type hypersensitivity. These suppressor cells effectively inhibited the induction of delayed-type hypersensitivity to BCG, but showed only weak effect on the expression of it.
摘要
在对卡介苗低反应的小鼠品系C3H/He中，迟发型超敏反应对牛分枝杆菌卡介苗的诱导受到抑制性T细胞的特异性抑制。将接种卡介苗小鼠的脾细胞过继转移到经环磷酰胺处理的受体中，证实了这些抑制性细胞的存在。抑制性细胞在静脉注射卡介苗后2至7天出现在小鼠脾脏中。它们对抗θ血清和补体敏感，不黏附于葡聚糖凝胶G - 10。用环磷酰胺对小鼠进行预处理可消除对迟发型超敏反应的抑制。这些抑制性细胞有效地抑制了对卡介苗迟发型超敏反应的诱导，但对其表达仅表现出微弱的影响。
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本文引用的文献
1
Difference in antigen-presenting ability of macrophages between high- and low-responder mice in delayed-type hypersensitivity to Mycobacterium bovis BCG.在对牛分枝杆菌卡介苗的迟发型超敏反应中，高反应性和低反应性小鼠巨噬细胞抗原呈递能力的差异。
Infect Immun. 1980 Jan;27(1):268-70. doi: 10.1128/iai.27.1.268-270.1980.
2
Separation of mouse spleen cells by passage through columns of sephadex G-10.通过葡聚糖凝胶G - 10柱对小鼠脾细胞进行分离。
J Immunol Methods. 1974 Aug;5(3):239-47. doi: 10.1016/0022-1759(74)90108-2.
3
Potentiation of T-cell-mediated immunity by selective suppression of antibody formation with cyclophosphamide.通过环磷酰胺选择性抑制抗体形成增强T细胞介导的免疫
J Exp Med. 1974 Jun 1;139(6):1529-39. doi: 10.1084/jem.139.6.1529.
4
Depression of the T cell phenomenon of contact sensitivity by T cells from unresponsive mice.无反应小鼠的T细胞对接触敏感性T细胞现象的抑制作用。
Nature. 1973 Jul 27;244(5413):227-8. doi: 10.1038/244227a0.
5
Tolerance and contact sensitivity to DNFB in mice. 3. Transfer of tolerance with "suppressor T cells".小鼠对二硝基氟苯的耐受性和接触敏感性。3. 用“抑制性T细胞”转移耐受性
J Immunol. 1974 Oct;113(4):1230-6.
6
7
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J Immunol. 1975 Nov;115(5):1212-6.
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