Bazargan Maryam, Mirzaei Masoud, Amiri Amirhassan, Mague Joel T
Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad 9177948974, Iran.
Khorasan Science and Technology Park (KSTP), 12th km of Mashhad-Quchan Road, Mashhad, Khorasan Razavi 9185173911, Iran.
Inorg Chem. 2023 Jan 9;62(1):56-65. doi: 10.1021/acs.inorgchem.2c02658. Epub 2022 Dec 28.
A series of two-dimensional (2D) polyoxometalate-based frameworks, [Ln(PDA)(HO)(PMoO)]·HO (Ln = La (); Ce (); Pr (); Nd (); PDA = 1,10-phenanthroline-2,9-dicarboxylate), have been synthesized and structurally characterized by various analytical techniques. Single-crystal X-ray diffraction reveals that - have a unique 2D layer structure in which Keggin anions have coordinated upward and downward the plane, and this feature makes them suitable candidates for surface binding of common drugs supramolecular and electrostatic interactions. Also, the ability of - (as the first polyoxomolybdate-containing frameworks) as sorbents for the extraction and quantitative determination of opioid drugs (morphine, methadone, and pethidine) was investigated by using dispersive micro-solid-phase extraction (D-μSPE) and high-performance liquid chromatography (HPLC). The method showed wide linear ranges in the range of 0.3 to 300 ng mg and low limits of detection (LODs) ranged from 0.1 to 0.2 ng mg of hair.
一系列基于二维（2D）多金属氧酸盐的框架化合物，[Ln(PDA)(HO)(PMoO)]·HO（Ln = La（）；Ce（）；Pr（）；Nd（）；PDA = 1,10 - 菲咯啉 - 2,9 - 二羧酸盐），已通过各种分析技术合成并进行了结构表征。单晶X射线衍射表明 - 具有独特的二维层状结构，其中Keggin阴离子在平面上下配位，这一特性使其成为通过超分子和静电相互作用与常见药物进行表面结合的合适候选物。此外，通过分散微固相萃取（D - μSPE）和高效液相色谱（HPLC）研究了 - （作为首个含多钼酸盐的框架化合物）作为吸附剂用于提取和定量测定阿片类药物（吗啡、美沙酮和哌替啶）的能力。该方法在0.3至300 ng mg的范围内显示出宽线性范围，毛发的检测限（LOD）低至0.1至0.2 ng mg。
