Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, 9177948974 Mashhad, Iran.
Department of Chemistry, Tulane University, New Orleans, Louisiana 70118, United States.
Inorg Chem. 2024 Feb 12;63(6):2877-2887. doi: 10.1021/acs.inorgchem.3c02130. Epub 2024 Jan 29.
Four self-assembled inorganic-organic hybrid materials, namely, H{Na(HO)[Gd(PDA)(HO)][BWO]}·4HO (), H{Na(HO)[Tb(PDA)(HO)][BWO]}·3HO (), H{Na(HO)[Er(PDA)(HO)][BWO]}·HO () (PDA = 1,10-phenanthroline-2,9-dicarboxylate), and [Pr(HO)(pydc-OH)][BWO]·12HO () (pydc-OH = 4-hydroxy-2,6-pyridinedicarboxylate), were hydrothermally synthesized and structurally characterized. Hybrids - are isostructural and contain a Keggin unit, which is linked to lanthanoids to produce distinct trinuclear lanthanoid building blocks. The fragments are connected by anion-π and hydrogen bonding interactions to create 3D networks. In hybrid 4, a trimeric Pr-organic species bearing a Keggin unit forms a 2D coordination polymer, and then hydrogen bonding interactions between 2D layers lead to the formation of a 3D structure. These polyoxometalate-based frameworks were used as sorbents for the dispersive microsolid-phase extraction (D-μSPE) of two anticancer drugs (doxorubicin and epirubicin) in human plasma samples. Analytes were quantified and separated using high-performance liquid chromatography with fluorescence detection (HPLC-FLD). The method's linearity was between 0.8-500 ng mL and 1.0-500 ng mL for the antineoplastic drugs doxorubicin and epirubicin, respectively. The limits of detection (S/N = 3) were in the range of 0.2-0.3 ng mL, while the precision was in the range of 3.5-4.3%. Finally, human plasma samples from patients treated with doxorubicin or epirubicin were analyzed by using the D-μSPE-HPLC-FLD method.
四种自组装的无机-有机杂化材料，即 H{Na(HO)[Gd(PDA)(HO)][BWO]}·4HO ()、H{Na(HO)[Tb(PDA)(HO)][BWO]}·3HO ()、H{Na(HO)[Er(PDA)(HO)][BWO]}·HO () (PDA = 1,10-邻菲罗啉-2,9-二羧酸)和[Pr(HO)(pydc-OH)][BWO]·12HO () (pydc-OH = 4-羟基-2,6-吡啶二甲酸)，通过水热合成法合成并进行了结构表征。这些杂化物是同构的，包含一个 Keggin 单元，该单元与镧系元素相连，形成独特的三聚体镧系元素构建块。这些片段通过阴离子-π 相互作用和氢键相互作用连接起来，形成 3D 网络。在杂化物 4 中，一个带有 Keggin 单元的三聚体 Pr-有机物种形成了一个 2D 配位聚合物，然后通过 2D 层之间的氢键相互作用形成了一个 3D 结构。这些基于多金属氧酸盐的骨架被用作分散微固相萃取 (D-μSPE) 的吸附剂，用于人血浆样品中两种抗癌药物 (阿霉素和表阿霉素) 的萃取。使用高效液相色谱法与荧光检测 (HPLC-FLD) 对分析物进行定量和分离。阿霉素和表阿霉素的线性范围分别为 0.8-500 ng mL 和 1.0-500 ng mL。检测限 (S/N = 3) 在 0.2-0.3 ng mL 范围内，精密度在 3.5-4.3%范围内。最后，使用 D-μSPE-HPLC-FLD 方法分析了接受阿霉素或表阿霉素治疗的患者的人血浆样品。
