Beaman B L, Goldstein E, Gershwin M E, Maslan S, Lippert W
Infect Immun. 1978 Dec;22(3):867-77. doi: 10.1128/iai.22.3.867-877.1978.
Congenitally athymic (nude, Nu/Nu), heterozygous (Nu/+), and Swiss Webster mice were exposed to virulent Nocardia asteroides GUH-2 inhaled from aerosols or administered intranasally. Clearance of the bacteria from the lungs was determined at 6 h and 1, 2, 3 and 7 days after infection. N. asteroides aspirated into the lungs from intranasal administration were killed less rapidly and induced more severe pulmonary infections than did comparable numbers of organisms inhaled from aerosols. Bacterial clearance and histological data indicated that nude mice were significantly more susceptible to nocardial infection than were heterozygous littermates or Swiss Webster mice. From these data we conclude that: (i) pulmonary defenses cope less well with intranasally administered N. asteroides than with aerosolized organisms, (ii) alveolar macrophages alone appear not to be an efficient barrier to nocardial infections, and (iii) T cells are important to pulmonary clearance and prevention of dissemination of N. asteroides from the lung.
将先天性无胸腺（裸鼠，Nu/Nu）、杂合子（Nu/+）和瑞士韦伯斯特小鼠暴露于通过气溶胶吸入或经鼻给药的强毒星形诺卡菌GUH-2。在感染后6小时以及1、2、3和7天测定肺部细菌的清除情况。与通过气溶胶吸入的等量细菌相比，经鼻给药吸入肺部的星形诺卡菌被杀灭的速度较慢，且会引发更严重的肺部感染。细菌清除和组织学数据表明，裸鼠比其杂合子同窝小鼠或瑞士韦伯斯特小鼠对诺卡菌感染的易感性显著更高。根据这些数据我们得出以下结论：（i）肺部防御机制对经鼻给药的星形诺卡菌的应对能力不如对雾化细菌的应对能力，（ii）仅肺泡巨噬细胞似乎并非诺卡菌感染的有效屏障，（iii）T细胞对肺部清除以及预防星形诺卡菌从肺部扩散至关重要。
