非侵入性血浆微生物游离脱氧核糖核酸测序在肺炎诊断和管理中的临床影响：一项单中心回顾性研究
Clinical Impact of Noninvasive Plasma Microbial Cell-Free Deoxyribonucleic Acid Sequencing for the Diagnosis and Management of Pneumonia: A Single-Center Retrospective Study.
作者信息
Foong Kap Sum, Mabayoje Mojolaoluwa, AlMajali Abeer
机构信息
Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, Massachusetts, USA.
Section of Infectious Diseases, University of Illinois College of Medicine, Peoria, Illinois, USA.
出版信息
Open Forum Infect Dis. 2022 Dec 2;9(12):ofac652. doi: 10.1093/ofid/ofac652. eCollection 2022 Dec.
Abstract
We present 23 cases of pneumonia (PCP) diagnosed with commercially available noninvasive plasma microbial cell-free deoxyribonucleic acid (mcfDNA) assay. Our findings suggest that plasma mcfDNA testing resulted in positive clinical impact for the diagnosis and treatment of PCP and coinfections in 82.6% of cases.
摘要
我们报告了23例通过市售非侵入性血浆微生物游离脱氧核糖核酸（mcfDNA）检测确诊的肺孢子菌肺炎（PCP）病例。我们的研究结果表明，血浆mcfDNA检测对82.6%的PCP病例及其合并感染的诊断和治疗产生了积极的临床影响。
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