Tuan Nguyen Tung, Thi Vinh Do An, Phan Thi Phuong, Lan Anh Le, Vu Minh Tam
Hematology and Blood Transfusion, Bach Mai Hospital, Hanoi, VNM.
Cureus. 2022 Nov 25;14(11):e31882. doi: 10.7759/cureus.31882. eCollection 2022 Nov.
Hairy cell leukemia (HCL) is a rare disease of mature B-cell neoplasms. Its name comes from the hair-like strands surrounding the cytoplasm of the cells, which are observed on peripheral blood or bone marrow smears. Leukemic cells mainly involve the spleen, peripheral blood, and bone marrow. The classical immunophenotyping of HCL includes overexpression of the B-cell surface antigens such as CD19, CD20, and CD22 and co-expression of CD25, CD103, CD11c, and CD123. Other markers including CD5, CD10, and CD38 are usually negative, in which CD38 is considered a poor prognostic factor. Herein, we report a case of HCL with atypical morphology and abnormal expression of both CD38 and CD10.
毛细胞白血病（HCL）是一种成熟B细胞肿瘤的罕见疾病。其名称源于在周围血或骨髓涂片上观察到的围绕细胞胞质的毛发样细丝。白血病细胞主要累及脾脏、外周血和骨髓。HCL的经典免疫表型包括B细胞表面抗原如CD19、CD20和CD22的过表达以及CD25、CD103、CD11c和CD123的共表达。其他标志物包括CD5、CD10和CD38通常为阴性，其中CD38被认为是一个不良预后因素。在此，我们报告一例具有非典型形态以及CD38和CD10异常表达的HCL病例。
