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1
Use of Ivermectin and Chlorine Dioxide for COVID-19 Treatment and Prophylaxis in Peru: A Narrative Review.伊维菌素和二氧化氯在秘鲁用于治疗和预防 COVID-19:一项叙述性综述。
Cureus. 2022 Nov 23;14(11):e31836. doi: 10.7759/cureus.31836. eCollection 2022 Nov.
2
Randomized clinical trial to compare the efficacy of ivermectin versus placebo to negativize nasopharyngeal PCR in patients with early COVID-19 in Peru (SAINT-Peru): a structured summary of a study protocol for randomized controlled trial.随机临床试验比较伊维菌素与安慰剂对秘鲁早期 COVID-19 患者鼻咽 PCR 转阴的疗效(SAINT-Peru):一项随机对照试验研究方案的结构化总结。
Trials. 2021 Apr 9;22(1):262. doi: 10.1186/s13063-021-05236-2.
3
Factors associated with the consumption of chlorine dioxide to prevent and treat COVID-19 in the Peruvian population: a cross-sectional study.与秘鲁人群中使用二氧化氯预防和治疗 COVID-19 相关的因素:一项横断面研究。
BMC Public Health. 2021 Nov 17;21(1):2109. doi: 10.1186/s12889-021-12191-9.
4
Ivermectin for preventing and treating COVID-19.伊维菌素预防和治疗 COVID-19。
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5
Ivermectin for preventing and treating COVID-19.伊维菌素预防和治疗 COVID-19。
Cochrane Database Syst Rev. 2021 Jul 28;7(7):CD015017. doi: 10.1002/14651858.CD015017.pub2.
6
Monoclonal Antibody Therapy For High-Risk Coronavirus (COVID 19) Patients With Mild To Moderate Disease Presentations (Archived)针对轻度至中度症状的高危冠状病毒(COVID-19)患者的单克隆抗体疗法(存档)
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Use of ivermectin and factors associated with the prevention and/or treatment of COVID-19: a cross-sectional online survey in the province of Chincha, Peru.在秘鲁钦查省进行的一项横断面在线调查:使用伊维菌素和与 COVID-19 预防和/或治疗相关的因素。
F1000Res. 2024 Jan 8;12:149. doi: 10.12688/f1000research.128675.2. eCollection 2023.
8
The SARS-CoV-2 Ivermectin Navarra-ISGlobal Trial (SAINT) to Evaluate the Potential of Ivermectin to Reduce COVID-19 Transmission in low risk, non-severe COVID-19 patients in the first 48 hours after symptoms onset: A structured summary of a study protocol for a randomized control pilot trial.SARS-CoV-2 依维莫司纳瓦拉-ISGlobal 试验(SAINT)评估依维莫司在症状出现后 48 小时内降低低危、非重症 COVID-19 患者 COVID-19 传播风险的潜力:一项随机对照试验方案的研究方案结构化总结。
Trials. 2020 Jun 8;21(1):498. doi: 10.1186/s13063-020-04421-z.
9
A COVID-19 prophylaxis? Lower incidence associated with prophylactic administration of ivermectin.一种 COVID-19 预防药物?伊维菌素预防性给药与较低的发病率相关。
Int J Antimicrob Agents. 2021 Jan;57(1):106248. doi: 10.1016/j.ijantimicag.2020.106248. Epub 2020 Nov 28.
10
Multidrug treatment for COVID-19.COVID-19 的多药治疗。
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本文引用的文献

1
Effect of Early Treatment with Ivermectin among Patients with Covid-19.COVID-19 患者早期使用伊维菌素治疗的效果。
N Engl J Med. 2022 May 5;386(18):1721-1731. doi: 10.1056/NEJMoa2115869. Epub 2022 Mar 30.
2
Evaluation of the effectiveness and safety of adding ivermectin to treatment in severe COVID-19 patients.评估在重症 COVID-19 患者的治疗中添加伊维菌素的有效性和安全性。
BMC Infect Dis. 2021 May 4;21(1):411. doi: 10.1186/s12879-021-06104-9.
3
Phase 2 randomized study on chloroquine, hydroxychloroquine or ivermectin in hospitalized patients with severe manifestations of SARS-CoV-2 infection.氯喹、羟氯喹或伊维菌素治疗严重 SARS-CoV-2 感染住院患者的 2 期随机研究。
Pathog Glob Health. 2021 Jun;115(4):235-242. doi: 10.1080/20477724.2021.1890887. Epub 2021 Mar 8.
4
Role of ivermectin in the prevention of SARS-CoV-2 infection among healthcare workers in India: A matched case-control study.伊维菌素在预防印度医护人员感染 SARS-CoV-2 中的作用:一项匹配病例对照研究。
PLoS One. 2021 Feb 16;16(2):e0247163. doi: 10.1371/journal.pone.0247163. eCollection 2021.
5
Chlorine dioxide and chlorine derivatives for the prevention or treatment of COVID-19: a systematic review.用于预防或治疗新型冠状病毒肺炎的二氧化氯和氯衍生物:一项系统综述
Rev Peru Med Exp Salud Publica. 2020 Oct-Dec;37(4):605-610. doi: 10.17843/rpmesp.2020.374.6330. Epub 2021 Feb 3.
6
Adverse reactions of drugs specifically used for treatment of SARS-CoV-2 infection.专门用于治疗新型冠状病毒2型感染的药物的不良反应。
Med Clin (Engl Ed). 2020 Nov 27;155(10):448-453. doi: 10.1016/j.medcle.2020.06.026. Epub 2020 Oct 30.
7
A five-day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness.一项为期五天的伊维菌素治疗 COVID-19 的疗程可能会缩短疾病的持续时间。
Int J Infect Dis. 2021 Feb;103:214-216. doi: 10.1016/j.ijid.2020.11.191. Epub 2020 Dec 2.
8
Therapeutic potential of ivermectin as add on treatment in COVID 19: A systematic review and meta-analysis.伊维菌素作为 COVID-19 附加治疗的治疗潜力:系统评价和荟萃分析。
J Pharm Pharm Sci. 2020;23:462-469. doi: 10.18433/jpps31457.
9
Use of Ivermectin Is Associated With Lower Mortality in Hospitalized Patients With Coronavirus Disease 2019: The Ivermectin in COVID Nineteen Study.使用伊维菌素与 COVID-19 住院患者的死亡率降低相关:COVID-19 中的伊维菌素研究。
Chest. 2021 Jan;159(1):85-92. doi: 10.1016/j.chest.2020.10.009. Epub 2020 Oct 13.
10
Pathophysiology and Potential Therapeutic Candidates for COVID-19: A Poorly Understood Arena.新型冠状病毒肺炎的病理生理学及潜在治疗候选药物:一个尚未被充分理解的领域。
Front Pharmacol. 2020 Sep 17;11:585888. doi: 10.3389/fphar.2020.585888. eCollection 2020.

伊维菌素和二氧化氯在秘鲁用于治疗和预防 COVID-19:一项叙述性综述。

Use of Ivermectin and Chlorine Dioxide for COVID-19 Treatment and Prophylaxis in Peru: A Narrative Review.

作者信息

Farfán-Castillo Angie de Los Milagros, Moreno-Núñez Rosangela Simone, Zárate-Yuyes Fátima Milagros, Fernández-Rodríguez Lissett Jeanette, Bardales-Zuta Victor Hugo

机构信息

School of Human Medicine, Antenor Orrego Private University, Trujillo, PER.

出版信息

Cureus. 2022 Nov 23;14(11):e31836. doi: 10.7759/cureus.31836. eCollection 2022 Nov.

DOI:10.7759/cureus.31836
PMID:36579243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9788901/
Abstract

The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, created a rapidly unfolding health crisis, especially in the initial phases of the pandemic. In the early stages of the pandemic, various strategies were proposed for COVID-19 prophylaxis and treatment with very little scientific evidence available. Among these proposed treatments were ivermectin and chlorine dioxide, which were both used widely in Peru for both disease prevention and treatment without considering their problematic side effects. For instance, ivermectin was part of an approved therapeutic scheme based on in vitro data, although its efficacy in humans was not demonstrated. In addition, chlorine dioxide was never shown to be effective but causes threatening side effects. In this article, we discuss current information regarding chlorine dioxide and ivermectin in the context of the COVID-19 pandemic, with a focus on experiences in Peru.

摘要

严重急性呼吸综合征冠状病毒2(SARS-CoV-2),即导致新冠肺炎的病毒,引发了一场迅速演变的健康危机,尤其是在疫情初期。在疫情早期,人们提出了各种新冠肺炎预防和治疗策略,但几乎没有科学证据。在这些提议的治疗方法中,有伊维菌素和二氧化氯,它们在秘鲁都被广泛用于疾病预防和治疗,而没有考虑其存在问题的副作用。例如,伊维菌素是基于体外数据的批准治疗方案的一部分,尽管其对人类的疗效尚未得到证实。此外,二氧化氯从未被证明有效,但会导致危险的副作用。在本文中,我们将在新冠肺炎疫情背景下讨论有关二氧化氯和伊维菌素的当前信息,重点是秘鲁的经验。