La Manna Sara, Florio Daniele, Di Natale Concetta, Marasco Daniela
Department of Pharmacy, University of Naples "Federico II", Naples, Italy.
Department of Chemical, Materials and Production Engineering, University of Naples "Federico II", Naples, Italy.
J Pept Sci. 2023 Aug;29(8):e3474. doi: 10.1002/psc.3474. Epub 2023 Jan 16.
Self-assembling hydrogels are receiving great attention for both biomedical and technological applications. Self-assembly of protein/peptides as well as organic molecules is commonly induced in response to external triggers such as changes of temperature, concentration, or pH. An interesting strategy to modulate the morphology and mechanical properties of the gels implies the use of metal ions, where coordination bonds regulate the dynamic cross-linking in the construction of hydrogels, and coordination geometries, catalytic, and redox properties of metal ions play crucial roles. This review aims to discuss recent insights into the supramolecular assembly of hydrogels involving metal ions, with a focus on self-assembling peptides, as well as applications of metallogels in biomedical fields including tissue engineering, sensing, wound healing, and drug delivery.
自组装水凝胶在生物医学和技术应用方面都备受关注。蛋白质/肽以及有机分子的自组装通常是由外部触发因素诱导的，如温度、浓度或pH值的变化。一种调节水凝胶形态和机械性能的有趣策略是使用金属离子，其中配位键在水凝胶的构建中调节动态交联，金属离子的配位几何结构、催化和氧化还原性质起着关键作用。本文综述旨在讨论近期关于涉及金属离子的水凝胶超分子组装的见解，重点是自组装肽，以及金属凝胶在包括组织工程、传感、伤口愈合和药物递送在内的生物医学领域的应用。
