Torgyán S, Ady E, Wagner L, Neumann T, Béres G, Csányi M
Int J Clin Pharmacol Biopharm. 1978 Dec;16(12):610-1.
The gastrointestinal bleeding during treatment with indomethacin, aspirin, phenylbutazone and sodium salicylate in healthy human subjects was determined. Gastrointestinal blood loss was determined by the Cr51-labelled erythrocyte method. The method was modified by us. Collected stool was incinerated and radioactivity of ashes was determined. Furthermore, rheumatic patients were treated for 4 weeks with indomethacin alone or with indomethacin combined with sodium salicylate. The gastrointestinal blood loss was determined on the last 4 days of treatment. It was found that blood loss was significantly reduced by combined treatment in comparison to monotherapy with indomethacin, while combined treatment had a marked anti-rheumatic effect.
测定了健康人体受试者在使用吲哚美辛、阿司匹林、保泰松和水杨酸钠治疗期间的胃肠道出血情况。胃肠道失血量采用铬51标记红细胞法测定。该方法由我们进行了改进。收集的粪便进行焚烧，并测定灰烬的放射性。此外，对风湿性患者单独使用吲哚美辛或吲哚美辛与水杨酸钠联合治疗4周。在治疗的最后4天测定胃肠道失血量。结果发现，与单独使用吲哚美辛治疗相比，联合治疗可显著减少失血量，同时联合治疗具有明显的抗风湿作用。
