Department of Neuroscience and Behavioral Sciences, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Dev Neurosci. 2023;45(1):27-36. doi: 10.1159/000528846. Epub 2022 Dec 29.
The aim of the study was to investigate three aspects of auditory function (auditory acuity, cochlear dysfunction, and auditory processing) in adolescents with fetal alcohol exposure without phenotypic changes. Fifty-one adolescents with and without intrauterine exposure to alcohol were selected from a cohort study. The summons, evaluation, and analysis of the results were carried out blindly regarding the respective exposure to alcohol. The auditory tests were pure-tone audiometry, transient otoacoustic emissions, and behavioral assessment of auditory processing (speech-in-noise, dichotic digits, and gap-in-noise). After testing, 45 adolescents were included in the evaluation and were divided into exposed (n = 22) and non-exposed (n = 23) groups. Hearing loss was identified in one subject in the exposed group (4.5%). In the absence of hearing loss, there were no significant differences in tonal thresholds or in the magnitudes of the sensory (cochlear) responses between groups (p > 0.05). There was also no difference between the two groups regarding performance on the processing tests (speech-in-noise p = 0.71, dichotic p = 0.94, and gap-in-noise p = 0.33). However, the exposed group had more cases of hearing disorders (hearing loss plus auditory processing disorders) than the non-exposed group (22.7% vs. 4.3%).
这项研究的目的是调查 51 名宫内暴露于酒精的青少年与非暴露于酒精的青少年在听觉功能(听觉敏锐度、耳蜗功能障碍和听觉处理)方面的三个方面。在一项队列研究中,从队列研究中选择了 51 名宫内暴露于酒精和未暴露于酒精的青少年。在各自暴露于酒精的情况下,对传唤、评估和结果分析进行了盲法处理。听觉测试包括纯音听力测试、瞬态耳声发射和听觉处理的行为评估(噪声中的言语、双听数字和噪声中的间隙)。测试后,45 名青少年被纳入评估,并分为暴露组(n = 22)和非暴露组(n = 23)。在暴露组中有一名受试者被发现有听力损失(4.5%)。在没有听力损失的情况下,两组之间的音调阈值或感觉(耳蜗)反应幅度没有显著差异(p > 0.05)。在处理测试方面,两组之间的表现也没有差异(噪声中的言语 p = 0.71,双听 p = 0.94,噪声中的间隙 p = 0.33)。然而,暴露组的听力障碍(听力损失加听觉处理障碍)病例比非暴露组多(22.7%比 4.3%)。