González-Darder J, Barberá J, Alamo J, Garcia-Vázquez F
Department of Neurosurgery, Faculty of Medicine, University of Cádiz, Spain.
Neurosurgery. 1987 Aug;21(2):215-7. doi: 10.1227/00006123-198708000-00014.
The role of microfascicular double ligation and interligature coagulation in the prevention of painful neuroma was studied in an experimental model of section of the sciatic nerve in the rat. The experimental parameters used were the onset of autotomy and the weekly autotomy score. The autotomy of the denervated limb is a behavioral pattern that occurs in the experimental animal after the severing of peripheral nerves and has been related to anomalous electrical activity originating from the neuroma. Microfascicular ligation was performed immediately after section of the sciatic nerve or 10 days later. The results were compared to those of control groups treated with simple nerve section or simple neuroma resection 10 days after nerve section. The results show that immediate or delayed microfascicular ligation has no effect on pain as measured by the development of autotomy.
在大鼠坐骨神经切断的实验模型中，研究了微束双结扎和结扎间凝固在预防疼痛性神经瘤方面的作用。所使用的实验参数为自切的起始时间和每周的自切评分。去神经肢体的自切是实验动物在周围神经切断后出现的一种行为模式，并且与源自神经瘤的异常电活动有关。在坐骨神经切断后立即或10天后进行微束结扎。将结果与在神经切断10天后接受单纯神经切断或单纯神经瘤切除治疗的对照组结果进行比较。结果表明，通过自切的发展来衡量，即时或延迟的微束结扎对疼痛没有影响。
