González-Darder J, Barberá J, Abellán M J, Mora A
J Neurosurg. 1985 Nov;63(5):754-8. doi: 10.3171/jns.1985.63.5.0754.
In this experimental study, microsurgical centrocentral anastomosis was applied to an experimental model of painful terminal neuroma resulting from left sciatic nerve section in the rat. The anastomosis consisted of end-to-end suturing of the sciatic nerve fascicles to the tibial branch, with the interposition of a nerve graft taken from the same anastomosed fascicle. As a control parameter for the experiment, the autotomy which follows sciatic nerve section in the rat was evaluated. Autotomy is considered an objective indication of abnormal sensations that are provoked by the formation of a terminal neuroma. Histological study of the proximal stump of the sciatic nerve was also performed. The observation period was 10 weeks. The study demonstrates that centrocentral anastomosis reduces the size of the neuroma formation and the incidence of autotomy.
在本实验研究中，将显微外科中央-中央吻合术应用于大鼠左侧坐骨神经切断所致疼痛性终末神经瘤的实验模型。吻合术包括将坐骨神经束与胫神经分支进行端端缝合，并在其间植入取自同一吻合束的神经移植物。作为实验的对照参数，对大鼠坐骨神经切断后出现的自残行为进行了评估。自残被认为是终末神经瘤形成所引发的异常感觉的客观指标。还对坐骨神经近端残端进行了组织学研究。观察期为10周。该研究表明，中央-中央吻合术可减小神经瘤形成的大小并降低自残的发生率。
