Newman R B, Gill P J, Campion S, Katz M
Department of Obstetrics and Gynecology, Children's Hospital, San Francisco.
Obstet Gynecol. 1987 Nov;70(5):701-5.
The clinical significance of low-amplitude, high-frequency contractions was examined during pregnancy in 142 women who underwent daily ambulatory tocodynamometry between 23-36 weeks' gestation. The results indicate that patients destined to develop preterm labor had this contractility pattern significantly more often than did their counterparts who delivered at term (13.5 versus 9.2%; P less than .01). Parity and gestational age had no effect on the occurrence of low-amplitude, high-frequency contractility, but this pattern was also significantly more prevalent in the presence of multifetal gestations, independent of the occurrence of preterm labor. The institution of tocolytic therapy was accompanied by a 50% decrease in the proportion of time occupied by low-amplitude, high-frequency contractions. Although this contraction pattern occurred significantly more often among patients who later developed preterm labor, calculations of its predictive values, specificity, and sensitivity indicate that its presence has relatively limited clinical significance.
对142名在妊娠23至36周期间每天进行动态宫缩图监测的孕妇，研究了低振幅、高频宫缩的临床意义。结果表明，注定会发生早产的患者出现这种收缩模式的频率明显高于足月分娩的患者（13.5%对9.2%；P<0.01）。产次和孕周对低振幅、高频收缩的发生没有影响，但这种模式在多胎妊娠中也明显更普遍，与早产的发生无关。使用宫缩抑制剂治疗后，低振幅、高频宫缩所占时间比例下降了50%。虽然这种收缩模式在后来发生早产的患者中出现的频率明显更高，但其预测价值、特异性和敏感性的计算表明，它的存在具有相对有限的临床意义。
