Peng Hailing, Han Liu, Tan Yuyong, Chu Yi, Lv Liang, Liu Deliang, Zhu Hongyi
Department of Gastroenterology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Research Center of Digestive Disease, Central South University, Changsha, Hunan, China.
Front Oncol. 2022 Dec 13;12:1003895. doi: 10.3389/fonc.2022.1003895. eCollection 2022.
Schwannomas are tumors arising from Schwan cells of the neural sheath, which rarely occur in the gastrointestinal tract. The aim of the present study was to analyze the clinicopathological features and treatment outcomes of gastrointestinal schwannomas (GISs).
Patients who were diagnosed with GISs in our hospital from January 2010 to December 2021 were selected. Data about demographic characteristics, clinical symptoms, treatment methods and outcomes, pathological results, and follow-up results were retrospectively collected and analyzed.
A total of 78 patients with 79 GISs were included, the female-to-male ratio was 55:23, and the average age was 52.12 ± 12.26 years. One-third (26/78) of the patients were asymptomatic. A total of 79 GISs were removed, and the average size was 3.63 ± 2.03 cm (range, 0.3-10 cm). As for tumor location, 54 GISs were located in the stomach, 14 in the esophagus, 2 in the duodenum, 6 in the colorectum (4 in the colon and 2 in the rectum), and the other 3 in the small intestine. A total of 23 and 55 patients underwent endoscopic and surgical resections, respectively. Compared with surgical resection, endoscopic resection is associated with a smaller diameter, lower cost, and shorter hospital stay. Pathological results revealed that S100 was positive in all the GISs. No recurrence was noticed during a median follow-up of 45 months (range, 6-148 months).
GISs are rare gastrointestinal tumors with favorable prognoses, which are most commonly seen in the stomach and diagnosed by pathological findings with immunohistochemical staining. Surgical resection remains the standard method for removing GISs, while endoscopic resection may serve as an alternative method for selected patients with GISs and may be attempted in GISs with a diameter of <3 cm and no signs of malignancy.
施万细胞瘤起源于神经鞘的施万细胞，很少发生于胃肠道。本研究旨在分析胃肠道施万细胞瘤（GIS）的临床病理特征及治疗效果。
选取2010年1月至2021年12月在我院诊断为GIS的患者。回顾性收集并分析患者的人口统计学特征、临床症状、治疗方法及效果、病理结果和随访结果。
共纳入78例患者的79个GIS，男女比例为55:23，平均年龄为52.12±12.26岁。三分之一（26/78）的患者无症状。共切除79个GIS，平均大小为3.63±2.03 cm（范围0.3 - 10 cm）。肿瘤位置方面，54个GIS位于胃，14个位于食管，2个位于十二指肠，6个位于结直肠（4个在结肠，2个在直肠），另外3个位于小肠。分别有23例和55例患者接受了内镜切除和手术切除。与手术切除相比，内镜切除的肿瘤直径较小、费用较低且住院时间较短。病理结果显示所有GIS的S100均为阳性。中位随访45个月（范围6 - 148个月）期间未发现复发。
GIS是一种罕见的胃肠道肿瘤，预后良好，最常见于胃，通过免疫组化染色的病理检查确诊。手术切除仍是切除GIS的标准方法，而内镜切除可作为部分GIS患者的替代方法，对于直径<3 cm且无恶性征象的GIS可尝试使用。
