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肺硬化性肺细胞瘤的治疗及术后随访:一例报告

Treatment and post-operative follow-up of pulmonary sclerosing pneumocytoma: A case report.

作者信息

Barnes Katherine E, Wile Rachel K, Banks Kian C, Velotta Jeffrey B

机构信息

School of Medicine, University of California, San Francisco (UCSF), San Francisco, CA, USA.

Department of Surgery, UCSF East Bay, Oakland, CA, USA.

出版信息

Ann Med Surg (Lond). 2022 Nov 5;84:104836. doi: 10.1016/j.amsu.2022.104836. eCollection 2022 Dec.

Abstract

INTRODUCTION AND IMPORTANCE

Pulmonary sclerosing pneumocytoma (PSP) is a rare tumor thought to originate from respiratory epithelial cells. It is usually benign, but may rarely metastasize to lymph nodes. Surgeons face unique challenges in diagnosis and management of this condition, and ideal surgical management is yet to be established.

CASE PRESENTATION

48-year-old woman with a 7 × 7 mm pulmonary lesion discovered incidentally on computerized tomography (CT) imaging, which grew to 9 mm over the following year. Seven years later, follow-up imaging revealed that the mass had grown to 1.3 cm in largest dimension. Surgery was recommended and the mass was resected via a right video-assisted thoracic surgery (VATS) middle lobectomy with mediastinal lymph node dissection. All lymph nodes were negative and the patient's postoperative course was unremarkable.

CLINICAL DISCUSSION

There are few evidence-based guidelines available on the treatment and postoperative surveillance of PSP. Research has shown comparable recurrence-free survival rates for sublobar resection and lobectomy, though recurrence can occur, especially following sublobar resection in larger or more centrally-located tumors. In absence of established guidelines, it was decided to follow this patient according to NCCN guidelines for surveillance of early-stage non-small cell lung cancer due to potential risk of recurrence.

CONCLUSION

This case report adds to the limited literature on PSP and depicts a possible treatment and postoperative follow-up plan. Right VATS middle lobectomy can effectively treat some cases of central PSP. In absence of established guidelines for postoperative follow-up of PSP, NCCN guidelines may outline one possible strategy for postoperative management.

摘要

引言与重要性

肺硬化性细胞瘤(PSP)是一种罕见肿瘤,被认为起源于呼吸上皮细胞。它通常为良性,但极少可转移至淋巴结。外科医生在该疾病的诊断和治疗上面临独特挑战,理想的手术治疗方案尚未确立。

病例介绍

一名48岁女性,在计算机断层扫描(CT)成像时偶然发现一个7×7毫米的肺部病变,在接下来的一年中增长至9毫米。七年后,随访成像显示该肿块最大直径已增长至1.3厘米。建议进行手术,通过右侧电视辅助胸腔镜手术(VATS)中叶切除术并进行纵隔淋巴结清扫切除了肿块。所有淋巴结均为阴性,患者术后病程平稳。

临床讨论

关于PSP的治疗和术后监测,几乎没有基于证据的指南。研究表明,亚肺叶切除和肺叶切除的无复发生存率相当,不过仍可能复发,尤其是较大或位于中央的肿瘤进行亚肺叶切除后。由于缺乏既定指南,鉴于存在复发的潜在风险,决定根据美国国立综合癌症网络(NCCN)早期非小细胞肺癌监测指南对该患者进行随访。

结论

本病例报告补充了关于PSP的有限文献,并描述了一种可能的治疗及术后随访方案。右侧VATS中叶切除术可有效治疗部分中央型PSP病例。由于缺乏PSP术后随访的既定指南,NCCN指南可能概述了一种术后管理的可能策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d9a/9793125/c77e538413c2/gr1.jpg

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