Hashemi Shahri Seyyed Hamed, Soltani Ghasem, Abbasi Teshnizi Mohammad, Moeinipour Aliasghar, Tayyebi Mohammad, Javidi Dasht Bayaz Reza, Abedi Farshad, Ghavami Vahid, Amini Shahram, Mohammadpour Amir Hooshang
Department of Clinical pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Anesthesia, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Avicenna J Phytomed. 2022 Nov-Dec;12(6):589-601. doi: 10.22038/AJP.2022.20908.
The aim of this study was to evaluate the effect of crocin on the prevention of atrial fibrillation after coronary artery bypass grafting (CABG) and heart valve replacement.
100 patients who were scheduled for CABG or heart valve replacement surgeries were randomly assigned into two groups of treatment and placebo. In the treatment group, patients received crocin tablets from three days prior to surgery and on the first three postoperative days (for a total of six days). During the first three days after surgery, postoperative atrial fibrillation (POAF) was assessed by electrocardiogram monitoring. Prooxidant-antioxidant balance (PAB) and c-reactive protein (CRP) levels were also assessed.
POAF developed in 7 patients in the treatment group versus 18 patients in the control (p=0.02). PAB levels were significantly lower in the crocin group (p<0.001), while differences in CRP levels were insignificant (p=0.39).
It seems that prophylactic use of crocin is effective in reducing the incidence of POAF in patients undergoing heart surgeries.
本研究旨在评估藏红花素对冠状动脉旁路移植术（CABG）和心脏瓣膜置换术后预防房颤的效果。
将100例计划进行CABG或心脏瓣膜置换手术的患者随机分为治疗组和安慰剂组。治疗组患者在手术前三天及术后头三天服用藏红花素片（共六天）。术后头三天，通过心电图监测评估术后房颤（POAF）情况。还评估了促氧化剂-抗氧化剂平衡（PAB）和C反应蛋白（CRP）水平。
治疗组有7例患者发生POAF，而对照组有18例（p = 0.02）。藏红花素组的PAB水平显著较低（p < 0.001），而CRP水平差异不显著（p = 0.39）。
似乎预防性使用藏红花素可有效降低心脏手术患者POAF的发生率。
