Chao Hsi-Chun, McLuckey Scott A
Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907-2084, United States.
Trends Analyt Chem. 2023 Jan;158. doi: 10.1016/j.trac.2022.116852. Epub 2022 Nov 26.
Gas-phase ion/ion reactions can be used to alter analyte ion-types for subsequent dissociation both quickly and efficiently without the need for altering analyte ionization conditions. This capability can be particularly useful when the ion-type that is most efficiently generated by the ionization method at hand does not provide the structural information of interest using available dissociation methods. This situation often arises in the analysis of lipids, which constitute a diverse array of chemical species with many possibilities for isomers. Gas-phase ion/ion reactions have been demonstrated to be capable of enhancing the ability of tandem mass spectrometry to characterize the structures of various lipid classes. This review summarizes progress to date in the application of gas-phase ion/ion reactions to lipid structural characterization.
气相离子/离子反应可用于快速、高效地改变分析物离子类型，以便后续解离，而无需改变分析物的电离条件。当手头的电离方法最有效地产生的离子类型无法使用现有的解离方法提供感兴趣的结构信息时，这种能力可能特别有用。这种情况在脂质分析中经常出现，脂质构成了各种各样的化学物质，存在许多异构体的可能性。气相离子/离子反应已被证明能够增强串联质谱表征各种脂质类别结构的能力。本综述总结了气相离子/离子反应在脂质结构表征应用方面迄今为止的进展。
