Mansour A M, Chess J, Henkind P
Department of Ophthalmology, Montefiore Medical Center/Albert Einstein College of Medicine, New York, N.Y.
Ophthalmic Res. 1987;19(3):164-9. doi: 10.1159/000265489.
Fibrinogen was injected in the vitreous cavity of 29 rabbits with follow-up for 75 days. Vitreous membrane formation was detected by indirect ophthalmoscopy and confirmed by histopathological study. Membrane formation was significantly more common in the fibrinogen group than in the control group. Fifteen days after injection, the membranes decreased in size and gave place to vitreous liquefaction in the majority of eyes in the fibrinogen group. Histochemical stains for fibrinogen were positive in half of the vitreous membranes. Fibrinogen is thought to be transformed into a long fibrin polymer forming a matrix for surrounding cells to proliferate in the vitreous. An effective fibrinolytic system in the vitreous explains the ultimate resolution of most of the fibrinogen-induced membranes. Simple fibrinogen injections do not provide a good model for long-term vitreous band formation, yet they add more evidence to the role of fibrin in the pathogenesis of vitreoproliferative diseases. The spontaneous resolution of some proliferative vitreoretinopathies parallels the reversibility of most of the fibrinogen-induced vitreous membranes.
将纤维蛋白原注射到29只兔子的玻璃体腔中，并进行75天的随访。通过间接检眼镜检查检测玻璃体膜形成，并通过组织病理学研究进行确认。纤维蛋白原组中膜形成明显比对照组更常见。注射后15天，纤维蛋白原组大多数眼睛中的膜尺寸减小并被玻璃体液化取代。半数玻璃体膜的纤维蛋白原组织化学染色呈阳性。纤维蛋白原被认为转化为长纤维蛋白聚合物，形成一个基质，供周围细胞在玻璃体中增殖。玻璃体中有效的纤维蛋白溶解系统解释了大多数纤维蛋白原诱导的膜最终的消退。单纯注射纤维蛋白原并不能提供一个用于长期玻璃体条索形成的良好模型，但它们为纤维蛋白在玻璃体增殖性疾病发病机制中的作用增加了更多证据。一些增殖性玻璃体视网膜病变的自发消退与大多数纤维蛋白原诱导的玻璃体膜的可逆性相似。
