通过N-杂环卡宾（NHC）催化的自由基接力从醛合成硫酯
Synthesis of Thioesters from Aldehydes via N-Heterocyclic Carbene (NHC) Catalyzed Radical Relay.
作者信息
Man Yunquan, Zeng Xiaojun, Xu Bo
机构信息
College of Chemistry and Chemical Engineering, Donghua University, 2999 North Renmin Road, 201620, Shanghai, China.
School of Chemistry and chemical Engineering, Nanchang University, 330031, Nanchang, Jiangxi, China.
出版信息
Chemistry. 2023 Mar 22;29(17):e202203716. doi: 10.1002/chem.202203716. Epub 2023 Feb 16.
We have developed an efficient N-heterocyclic carbene (NHC)-catalyzed thioesterification of aldehydes using N-thiosuccinimides as the thiolation reagent. This organocatalyzed transition involves the generation of sulfur radicals by single electron transfer of the Breslow enolate (generated from aldehyde and NHC catalyst) with N-thiosuccinimides. This method offers facile access to various highly functionalized thioesters and exhibits good chemical yields and functional group tolerance.
我们已经开发出一种高效的N-杂环卡宾（NHC）催化的醛的硫酯化反应，该反应使用N-硫代琥珀酰亚胺作为硫醇化试剂。这种有机催化的转变涉及通过Breslow烯醇盐（由醛和NHC催化剂生成）与N-硫代琥珀酰亚胺的单电子转移产生硫自由基。该方法能够方便地合成各种高度官能化的硫酯，并且具有良好的化学产率和官能团耐受性。
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