Cui Xuetao, Ma Xumin, Li Chunhai, Meng Hong, Han Chunchao
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, People's Republic of China.
Department of Radiology, Cheeloo College of Medicine, Qilu Hospital, Shandong University, Jinan, 250012, China.
Mol Biol Rep. 2023 Mar;50(3):2779-2793. doi: 10.1007/s11033-022-08233-z. Epub 2022 Dec 30.
Saponins, which exhibit many different biological and pharmacological activities, are present in a wide range of plant species and in some marine organisms. Notably, the researchers have found that saponins can activate the immune system in mammals. The strength of this function is closely related to the chemical structure of saponins. The present study of the structure-activity relationship suggests that aglycones, glycochains on aglycones and special functional groups of saponins affect the immune activity of saponins. This paper reviews the effects of different saponins on cellular immunity. As well as the structure-activity relationship of saponins. It is hoped that the information integrated in this paper will provide readers with information on the effects of saponins on cellular immunity and promote the further study of these compounds.
皂苷存在于多种植物物种和一些海洋生物中，具有许多不同的生物学和药理活性。值得注意的是，研究人员发现皂苷可以激活哺乳动物的免疫系统。这种功能的强度与皂苷的化学结构密切相关。目前对构效关系的研究表明，苷元、苷元上的糖链以及皂苷的特殊官能团会影响皂苷的免疫活性。本文综述了不同皂苷对细胞免疫的影响以及皂苷的构效关系。希望本文整合的信息能为读者提供有关皂苷对细胞免疫影响的信息，并促进对这些化合物的进一步研究。
