Karami Fath Mohsen, Akhavan Masouleh Ramtin, Afifi Negin, Loghmani Shirin, Tamimi Parham, Fazeli Alireza, Mousavian Seyed Ali, Falsafi Mohammad Mehdi, Barati Ghasem
Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.
School of Medicine, Alborz University of Medical Sciences, Alborz, Iran.
Pathol Res Pract. 2023 Jan;241:154279. doi: 10.1016/j.prp.2022.154279. Epub 2022 Dec 17.
The PI3K/Akt/mTOR signaling pathway is responsible for many cellular behaviors, including survival, growth, and proliferation. A newly identified RNA, circular RNA (circRNA), plays a crucial role in the regulation of gene expression. The upregulation of the PI3K/Akt pathway through dysregulated circRNAs promotes breast tumor initiation, growth, and progression. The dysregulation of PI3K/Akt-regulating circRNAs seems to be directly correlated with breast cancer clinical features, including overall survival, tumor size, cancer stage, and lymph node metastasis. In addition, targeting these circRNAs may be a promising option in cancer-targeted therapy. Understanding the molecular pathogenesis of the circRNA-PI3K/AKT axis may give the insight to develop new therapeutic and diagnostic approaches for breast cancer therapy. Here we reviewed the expression and functions of PI3K/AKT-regulating circRNAs, and their correlation with breast cancer clinical features. In addition, the potential of PI3K/AKT-regulating circRNAs as diagnostic/prognostic biomarkers or therapeutic targets was discussed.
PI3K/Akt/mTOR信号通路负责多种细胞行为，包括存活、生长和增殖。一种新发现的RNA，即环状RNA（circRNA），在基因表达调控中起关键作用。通过失调的circRNAs上调PI3K/Akt通路可促进乳腺肿瘤的起始、生长和进展。PI3K/Akt调节性circRNAs的失调似乎与乳腺癌临床特征直接相关，包括总生存期、肿瘤大小、癌症分期和淋巴结转移。此外，靶向这些circRNAs可能是癌症靶向治疗的一个有前景的选择。了解circRNA-PI3K/AKT轴的分子发病机制可能有助于开发新的乳腺癌治疗和诊断方法。在此，我们综述了PI3K/AKT调节性circRNAs的表达和功能，及其与乳腺癌临床特征的相关性。此外，还讨论了PI3K/AKT调节性circRNAs作为诊断/预后生物标志物或治疗靶点的潜力。
