State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, China.
Department of Neurosurgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, China.
Signal Transduct Target Ther. 2021 Nov 24;6(1):400. doi: 10.1038/s41392-021-00788-w.
Circular RNAs (circRNAs), covalently closed noncoding RNAs, are widely expressed in eukaryotes and viruses. They can function by regulating target gene expression, linear RNA transcription and protein generation. The phosphoinositide 3-kinase (PI3K)/AKT signaling pathway plays key roles in many biological and cellular processes, such as cell proliferation, growth, invasion, migration, and angiogenesis. It also plays a pivotal role in cancer progression. Emerging data suggest that the circRNA/PI3K/AKT axis modulates the expression of cancer-associated genes and thus regulates tumor progression. Aberrant regulation of the expression of circRNAs in the circRNA/PI3K/AKT axis is significantly associated with clinicopathological characteristics and plays an important role in the regulation of biological functions. In this review, we summarized the expression and biological functions of PI3K-AKT-related circRNAs in vitro and in vivo and assessed their associations with clinicopathological characteristics. We also further discussed the important role of circRNAs in the diagnosis, prognostication, and treatment of cancers.
环状 RNA（circRNAs）是共价闭合的非编码 RNA，广泛存在于真核生物和病毒中。它们可以通过调节靶基因表达、线性 RNA 转录和蛋白质生成来发挥作用。磷酸肌醇 3-激酶（PI3K）/AKT 信号通路在许多生物和细胞过程中发挥着关键作用，如细胞增殖、生长、侵袭、迁移和血管生成。它在癌症进展中也起着关键作用。新出现的数据表明，circRNA/PI3K/AKT 轴调节与癌症相关的基因表达，从而调节肿瘤进展。circRNA/PI3K/AKT 轴中 circRNA 表达的异常调节与临床病理特征显著相关，并在调节生物学功能方面发挥着重要作用。在这篇综述中，我们总结了 PI3K-AKT 相关 circRNAs 在体外和体内的表达和生物学功能，并评估了它们与临床病理特征的关系。我们还进一步讨论了 circRNAs 在癌症诊断、预后和治疗中的重要作用。
