Sino-German Joint Research Institute, Nanchang University, Nanchang, China.
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, China.
Food Chem. 2023 May 30;409:135257. doi: 10.1016/j.foodchem.2022.135257. Epub 2022 Dec 21.
Conjugated linoleic acid (CLA) is a collective term for the octadecadienoic acid isomers containing conjugated double bonds. This article reviewed CLA isomers from biological activities, biosynthesis mechanisms and analytical methods. The biological activities of CLA isomers in anti-obesity, cardiovascular protection, diabetes management and anti-cancer in vitro and in vivo were mainly reviewed. More attention has been paid to the production of the specific CLA isomer due to its biological activity. The biosynthesis methods of CLA isomers, such as dietary modification in ruminants and fermentation by microorganisms & enzymes, were systematically introduced. A rapid, accurate and economic analysis method will promote the research in both biological activities and biosynthesis mechanisms of CLA isomers. The merits of UV spectrometry, GC, HPLC, MS and CE used in the analysis of CLA isomers were also compared in detail. This paper aims to put into perspective the current status and future trends on CLA isomers.
共轭亚油酸（CLA）是指含有共轭双键的十八碳二烯酸异构体的统称。本文综述了 CLA 异构体在抗肥胖、心血管保护、糖尿病管理和抗癌方面的体外和体内生物活性、生物合成机制和分析方法。重点介绍了由于其生物活性而引起人们关注的特定 CLA 异构体的生产。系统介绍了 CLA 异构体的生物合成方法，如反刍动物的饮食改良和微生物及酶的发酵。一种快速、准确和经济的分析方法将促进 CLA 异构体的生物活性和生物合成机制的研究。还详细比较了 UV 光谱法、GC、HPLC、MS 和 CE 在 CLA 异构体分析中的优缺点。本文旨在全面阐述 CLA 异构体的现状和未来发展趋势。
