Department of Neurology, Beijing Tiantan Hospital, Beijing, China.
China National Clinical Research Center for Neurological Diseases, Beijing, China.
BMJ Open. 2022 Dec 30;12(12):e063520. doi: 10.1136/bmjopen-2022-063520.
To report the prevalence and distribution of lacunar stroke in different regions of China, as well as the demographical characteristics of symptomatic and asymptomatic lacunar stroke.
Cross-sectional study.
Data were derived from NESS-China Study that was conducted in 157 sites covering all 31 provinces, including 64 urban and 93 rural areas in mainland China between 1 September 2013 and 31 December 2013. Lacunar stroke was defined as being previously diagnosed according to the participants' medical history. Patients were further divided into symptomatic or asymptomatic groups, depending on whether they were initially diagnosed with neurological symptoms.
458 833 participants aged ≥20 years were enrolled in this study.
A total of 7520 participants (1.63%) were diagnosed with lacunar stroke. The peak rate of diagnosis was between the ages of 70 and 79 years in both men and women. Geographically, the age-standardised and sex-standardised prevalence was highest in Northeast China (2495.3/100 000 persons) and lowest in Southeast China (599.7/100 000 persons), showing a geographical disparity. Over 90% of patients with lacunar stroke were diagnosed in secondary or tertiary hospitals. Patients with symptomatic lacunar stroke had significantly different demographic characteristics in age, sex and geographical regions compared with those who were asymptomatic.
In this study, the prevalence and distribution of lacunar stroke were reported at population level across China. Special attention and prevention should be given to the age, sex and geographical groups that are vulnerable to lacunar stroke.
报告中国不同地区腔隙性卒中的患病率和分布情况，以及有症状和无症状腔隙性卒中患者的人口统计学特征。
横断面研究。
数据来自NESS-China 研究，该研究于 2013 年 9 月 1 日至 12 月 31 日在内地 31 个省的 157 个地点进行，包括 64 个城市和 93 个农村地区。腔隙性卒中的定义是根据参与者的病史进行的既往诊断。根据患者是否最初诊断为神经症状，将患者进一步分为有症状或无症状组。
本研究共纳入 458833 名年龄≥20 岁的参与者。
共有 7520 名参与者（1.63%）被诊断为腔隙性卒中。在男性和女性中，诊断高峰年龄均在 70 至 79 岁之间。从地域上看，东北地区的年龄标准化和性别标准化患病率最高（2495.3/10 万），东南地区最低（599.7/10 万），存在地域差异。超过 90%的腔隙性卒中患者在二级或三级医院就诊。与无症状腔隙性卒中患者相比，有症状腔隙性卒中患者在年龄、性别和地域方面具有显著不同的人口统计学特征。
本研究报告了中国人群腔隙性卒中的患病率和分布情况。应特别关注和预防易患腔隙性卒中的年龄、性别和地域群体。
