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Mage-D1 在大鼠牙胚中的动态表达及其在外胚间充质干细胞矿化中的潜在作用。

Dynamic expression of Mage-D1 in rat dental germs and potential role in mineralization of ectomesenchymal stem cells.

机构信息

Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Stomatological Hospital of Chongqing Medical University, Chongqing, China.

Department of Orthodontics, Hospital of Stomatology, Southwest Medical University, Luzhou, Sichuan, China.

出版信息

Sci Rep. 2022 Dec 30;12(1):22615. doi: 10.1038/s41598-022-27197-5.

DOI:10.1038/s41598-022-27197-5
PMID:36585447
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9803661/
Abstract

Mage-D1 (MAGE family member D1) is involved in a variety of cell biological effects. Recent studies have shown that Mage-D1 is closely related to tooth development, but its specific regulatory mechanism is unclear. The purpose of this study was to investigate the expression pattern of Mage-D1 in rat dental germ development and its differential mineralization ability to ectomesenchymal stem cells (EMSCs), and to explore its potential mechanism. Results showed that the expression of Mage-D1 during rat dental germ development was temporally and spatially specific. Mage-D1 promotes the proliferation ability of EMSCs but inhibits their migration ability. Under induction by mineralized culture medium, Mage-D1 promotes osteogenesis and tooth-forming ability. Furthermore, the expression pattern of Mage-D1 at E19.5 d rat dental germ is similar to p75 neurotrophin receptor (p75NTR), distal-less homeobox 1 (Dlx1) and msh homeobox 1 (Msx1). In addition, Mage-D1 is binding to p75NTR, Dlx1, and Msx1 in vitro. These findings indicate that Mage-D1 is play an important regulatory role in normal mineralization of teeth. p75NTR, Dlx1, and Msx1 seem to be closely related to the underlying mechanism of Mage-D1 action.

摘要

Mage-D1（MAGE 家族成员 D1）参与多种细胞生物学效应。最近的研究表明，Mage-D1 与牙齿发育密切相关，但具体的调控机制尚不清楚。本研究旨在探讨 Mage-D1 在大鼠牙胚发育中的表达模式及其对外胚间充质干细胞（EMSCs）的差异矿化能力，并探讨其潜在机制。结果表明，Mage-D1 在大鼠牙胚发育过程中的表达具有时间和空间特异性。Mage-D1 促进 EMSCs 的增殖能力，但抑制其迁移能力。在矿化培养基的诱导下，Mage-D1 促进成骨和牙形成能力。此外，E19.5d 大鼠牙胚中 Mage-D1 的表达模式与 p75 神经营养因子受体（p75NTR）、远侧同源盒 1（Dlx1）和 msx 同源盒 1（Msx1）相似。此外，Mage-D1 在体外与 p75NTR、Dlx1 和 Msx1 结合。这些发现表明 Mage-D1 在牙齿正常矿化中发挥重要的调节作用。p75NTR、Dlx1 和 Msx1 似乎与 Mage-D1 作用的潜在机制密切相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a1a/9803661/121baac2c38e/41598_2022_27197_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a1a/9803661/dfaea4f44de2/41598_2022_27197_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a1a/9803661/ad4f8b3fdffc/41598_2022_27197_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a1a/9803661/da5cc069349c/41598_2022_27197_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a1a/9803661/a3127df4bf3d/41598_2022_27197_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a1a/9803661/52ba3fa1e743/41598_2022_27197_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a1a/9803661/121baac2c38e/41598_2022_27197_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a1a/9803661/dfaea4f44de2/41598_2022_27197_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a1a/9803661/ad4f8b3fdffc/41598_2022_27197_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a1a/9803661/da5cc069349c/41598_2022_27197_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a1a/9803661/a3127df4bf3d/41598_2022_27197_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a1a/9803661/52ba3fa1e743/41598_2022_27197_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a1a/9803661/121baac2c38e/41598_2022_27197_Fig6_HTML.jpg

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