Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Department of Hematology, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
BMC Nephrol. 2022 Dec 30;23(1):415. doi: 10.1186/s12882-022-03038-5.
Platelet-to-lymphocyte ratio (PLR) has been used as a potential biomarker of inflammation-related diseases, but its role in the peritoneal dialysis-related peritonitis (PDRP) is still uncertain. This study was aimed to investigate the association between PLR and the new-onset PDRP in peritoneal dialysis (PD) patients.
In this multicenter retrospective study, 1378 PD Chinese PD patients were recruited from four centers, who were divided into the high PLR group (HPG) and the low PLR group (LPG) according to the cutoff value of PLR. The correlation between PLR and the new-onset PDRP was assessed using the Cox regression model analysis.
During follow-up, 121 new-onset PDRP events were recorded. Kaplan-Meier survival curve showed a higher risk of new-onset PDRP in the HPG (log-rank test, P < 0.001). After adjusting for confounding factors, the Cox regression model showed the risk of new-onset PDRP was higher in the HPG than that in the LPG (HR 1.689, 95%CI 1.096-2.602, P = 0.017). Competitive risk model analysis showed that significant differences still existed between the two PLR groups in the presence of other competitive events (P < 0.001).
PLR is independently associated with the new-onset PDRP in PD patients.
血小板与淋巴细胞比值（PLR）已被用作炎症相关疾病的潜在生物标志物，但它在腹膜透析相关腹膜炎（PDRP）中的作用尚不确定。本研究旨在探讨 PLR 与腹膜透析（PD）患者新发 PDRP 的关系。
本多中心回顾性研究纳入了来自四个中心的 1378 名中国 PD 患者，根据 PLR 的截断值将其分为高 PLR 组（HPG）和低 PLR 组（LPG）。采用 Cox 回归模型分析 PLR 与新发 PDRP 的相关性。
在随访期间，记录到 121 例新发 PDRP 事件。Kaplan-Meier 生存曲线显示 HPG 组新发 PDRP 的风险较高（对数秩检验，P<0.001）。调整混杂因素后，Cox 回归模型显示 HPG 组新发 PDRP 的风险高于 LPG 组（HR 1.689，95%CI 1.096-2.602，P=0.017）。竞争风险模型分析显示，在存在其他竞争事件的情况下，两组间仍存在显著差异（P<0.001）。
PLR 与 PD 患者新发 PDRP 独立相关。
