甘油三酯-葡萄糖指数升高与慢性腹膜透析患者腹膜炎首发相关。
Elevated triglyceride-glucose index predisposes to the initial episode of peritonitis in chronic peritoneal dialysis patients.
机构信息
Department of Nephrology, the Second Affiliated Hospital of Anhui Medical University, Anhui, China.
出版信息
Ren Fail. 2023;45(2):2267127. doi: 10.1080/0886022X.2023.2267127. Epub 2023 Oct 9.
OBJECTIVE
The serum triglyceride-glucose (TyG) index is a marker of inflammation. However, the relationship between TyG index and peritoneal dialysis-related peritonitis (PDRP) is unclear. This study aimed to investigate the potential relationship between the baseline TyG index and the initial episode of PDRP.
METHODS
A total of 208 peritoneal dialysis (PD) patients were enrolled from January 1, 2012, to December 31, 2019 and followed up until December 31, 2022. They were divided into 2 groups according to the median TyG. The primary outcome was the occurrence of the initial episode of PDRP while on PD therapy. Kaplan-Meier curves and Cox regression analyses were used to examine the association between them.
RESULTS
Eighty-five initial episodes of PDRP were identified. The risk of PDRP was higher in the high-TyG index group ( = 0.030). Multivariate Cox regression analysis showed a higher risk of PDRP in patients with a high TyG index ( = 1.800, 95% 1.511-2.815, = 0.010).
CONCLUSION
The baseline serum TyG index was an independent risk factor for the initial episode of PDRP in chronic PD patients.
目的
血清三酰甘油-葡萄糖（TyG）指数是炎症的标志物。然而，TyG 指数与腹膜透析相关腹膜炎（PDRP）之间的关系尚不清楚。本研究旨在探讨基线 TyG 指数与首次发生 PDRP 之间的潜在关系。
方法
本研究纳入了 208 例 2012 年 1 月 1 日至 2019 年 12 月 31 日期间接受腹膜透析（PD）治疗的患者，并随访至 2022 年 12 月 31 日。根据 TyG 的中位数将他们分为两组。主要结局是 PD 治疗期间首次发生 PDRP。Kaplan-Meier 曲线和 Cox 回归分析用于检验它们之间的关系。
结果
共确定了 85 例首次发生的 PDRP。高 TyG 指数组的 PDRP 风险更高（=0.030）。多变量 Cox 回归分析显示，TyG 指数较高的患者发生 PDRP 的风险更高（=1.800，95%CI 为 1.511-2.815，=0.010）。
结论
慢性 PD 患者的基线血清 TyG 指数是首次发生 PDRP 的独立危险因素。
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