Aschner J L, Punsalang A, Maniscalco W M, Menegus M A
Department of Pediatrics, University of Rochester Medical Center, New York.
Pediatrics. 1987 Oct;80(4):535-9.
Malassezia furfur colonization of central venous catheters has been implicated in the pathogenesis of systemic infections with this lipid-dependent yeast. To determine the incidence of catheter colonization in our neonatal intensive care unit (NICU), 25 consecutively removed percutaneous central venous catheters were examined by rinsing the lumen with saline and plating the rinse fluid on Sabouraud dextrose agar overlaid with olive oil. M furfur grew from the lumina of eight catheters (32%). Surveillance skin cultures were performed in the NICU on two occasions to determine the prevalence of skin colonization with M furfur. M furfur was found on the skin of 64% of the infants. In contrast, only 3% (1/33) of healthy, nonhospitalized infants 2 to 8 weeks of age had skin colonized with M furfur. During the 5-month study period, two NICU infants had evidence of systemic infection with M furfur. We conclude that M furfur frequently colonizes both the skin and percutaneous central venous catheters in NICU infants. Further studies are needed to determine the relationship between skin colonization and catheter colonization, and the factors contributing to systemic disease with this organism.
糠秕马拉色菌在中心静脉导管上的定植与这种依赖脂质的酵母菌引起的全身感染的发病机制有关。为了确定我们新生儿重症监护病房（NICU）中导管定植的发生率，对25根连续拔除的经皮中心静脉导管进行了检查，方法是用盐水冲洗管腔，并将冲洗液接种在覆盖有橄榄油的沙氏葡萄糖琼脂平板上。8根导管（32%）的管腔中培养出了糠秕马拉色菌。在NICU对婴儿进行了两次监测性皮肤培养，以确定糠秕马拉色菌皮肤定植的患病率。64%的婴儿皮肤上发现了糠秕马拉色菌。相比之下，在2至8周龄的健康非住院婴儿中，只有3%（1/33）的婴儿皮肤有糠秕马拉色菌定植。在为期5个月的研究期间，两名NICU婴儿有糠秕马拉色菌全身感染的证据。我们得出结论，糠秕马拉色菌在NICU婴儿的皮肤和经皮中心静脉导管中都经常定植。需要进一步研究以确定皮肤定植与导管定植之间的关系，以及导致该病原体引起全身疾病的因素。
