The Third Department of Surgery, The Fourth Hospital of Hebei Medical University, 050011 Shijiazhuang, China.
The Third Department of Surgery, The Fourth Hospital of Hebei Medical University, 050011 Shijiazhuang, China.
Biomed Pharmacother. 2023 Feb;158:114180. doi: 10.1016/j.biopha.2022.114180. Epub 2022 Dec 30.
Gastric cancer (GC) remains one of the most common malignancies worldwide. Despite immune-checkpoint inhibitors (ICIs) has revolutionized cancer treatment and obtained durable clinical responses, only a fraction of GC patients benefit from it. As an important component of T cells, regulatory T cells (Tregs) play a vital role in the pathogenesis of GC, keep a core balance between immune suppression and autoimmunity, and function as predictive biomarkers for prognosis of GC patients. In this review, we discuss the role of Tregs in the pathogenesis of GC, and targeting Tregs via influencing their transcription factor, migration, co-stimulatory receptors, immune checkpoints, and cytokines. We also focus on the currently important findings of Tregs metabolism including amino acid, fatty acid, and lactic acid metabolism of GC. The emerging role of microbiome and clinical combined therapy in modulating Tregs in GC treatment is also summarized. Meanwhile, this review recapitulates a novel regulator, magnesium, is involved in mediating Tregs in GC. These research advances on Treg-related strategies provide new insights and challenges for GC progression, treatment, and prognosis. And we hope our review can stimulate further discovery and implication of mediators and pathways targeting Tregs.
胃癌（GC）仍然是全球最常见的恶性肿瘤之一。尽管免疫检查点抑制剂（ICIs）彻底改变了癌症治疗，并获得了持久的临床反应，但只有少数 GC 患者从中受益。调节性 T 细胞（Tregs）作为 T 细胞的重要组成部分，在 GC 的发病机制中发挥着重要作用，在免疫抑制和自身免疫之间保持着核心平衡，并作为 GC 患者预后的预测生物标志物。在这篇综述中，我们讨论了 Tregs 在 GC 发病机制中的作用，并通过影响其转录因子、迁移、共刺激受体、免疫检查点和细胞因子来靶向 Tregs。我们还重点介绍了 Tregs 代谢的当前重要发现，包括 GC 中氨基酸、脂肪酸和乳酸代谢。微生物组和临床联合治疗在调节 GC 中 Tregs 方面的新兴作用也得到了总结。同时，本综述回顾了一种新型调节剂镁，它参与了 GC 中 Tregs 的调节。这些关于 Treg 相关策略的研究进展为 GC 的进展、治疗和预后提供了新的见解和挑战。我们希望我们的综述能够激发对 Tregs 靶向调节剂和途径的进一步发现和应用。
