Department of Pathology, Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania.
Department of Immunology, Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania.
Cancer Treat Rev. 2023 Nov;120:102629. doi: 10.1016/j.ctrv.2023.102629. Epub 2023 Sep 23.
Gastric cancer (GC) is a highly aggressive malignancy that remains a significant contributor to cancer-related mortality worldwide, despite a decline in incidence in recent years. Early-stage GC poses a diagnostic challenge due to its asymptomatic nature, leading to poor prognoses for most patients. Conventional treatment approaches, including chemotherapy and surgery, have shown limited efficacy in improving outcomes for GC patients. The advent of immune checkpoint inhibitors (ICIs) has revolutionized cancer therapy, yielding durable responses across various malignancies. However, the clinical benefits of ICIs in GC have been modest, underscoring the need for a comprehensive understanding of immune cell functions within the GC tumor microenvironment (TME). Regulatory T cells (Tregs), a subset of T lymphocytes, play a pivotal role in GC development and progression and serve as prognostic biomarkers for GC patients. This review aims to elucidate the multifaceted roles of Tregs in the pathogenesis, progression, and prognosis of gastric cancer, and establish their actual and future potential as therapeutic targets. By providing insights into the intricate interplay between Tregs and the TME, this review strives to stimulate further investigation and facilitate the development of targeted Treg-based therapeutic strategies for GC.
胃癌（GC）是一种高度侵袭性的恶性肿瘤，尽管近年来发病率有所下降，但仍是全球癌症相关死亡的主要原因。早期胃癌由于其无症状性质，给大多数患者带来了不良预后，因此诊断具有挑战性。包括化疗和手术在内的传统治疗方法在改善 GC 患者的预后方面效果有限。免疫检查点抑制剂（ICIs）的出现彻底改变了癌症治疗，在各种恶性肿瘤中产生了持久的反应。然而，ICIs 在 GC 中的临床获益有限，这突显了需要全面了解 GC 肿瘤微环境（TME）中免疫细胞的功能。调节性 T 细胞（Tregs）是 T 淋巴细胞的一个亚群，在 GC 的发生和发展中起着关键作用，并作为 GC 患者的预后生物标志物。本综述旨在阐明 Tregs 在胃癌发病机制、进展和预后中的多方面作用，并确定其作为治疗靶点的实际和未来潜力。通过深入了解 Tregs 与 TME 之间的复杂相互作用，本综述旨在激发进一步的研究，并促进针对 GC 的基于 Treg 的靶向治疗策略的发展。
