Qi Junjun, Ye Yingying, Sun Rui, Zhen Rui, Zhou Xiao
Department of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou 310028, China.
Jing Hengyi School of Education, Hangzhou Normal University, Hangzhou 311121, China.
J Affect Disord. 2023 Mar 1;324:354-363. doi: 10.1016/j.jad.2022.12.119. Epub 2022 Dec 28.
High comorbidity between posttraumatic stress disorder (PTSD) and depression among adolescents often follows severe traumatic events. Models on the pathway to comorbidity dispute greatly and how PTSD and depression get comorbidity, remain unclear.
A follow-up investigation was conducted of 424 adolescent survivors of the Jiuzhaigou earthquake at 12 months (T1) and 27 months (T2).
Contemporaneous network analysis and cross-lagged panel network analysis showed that PTSD and depression are two separate disorders with strong associations via links between dysphoric symptoms of PTSD and somatic or non-somatic symptoms of depression. However, the association weakened from T1 to T2, and internal connections between symptoms within each disorder became stronger.
We only measured the comorbidity of PTSD and depression at two time points following the earthquake, which may limit the long-term applicability of our findings following trauma.
The findings also showed that the centrality in contemporaneous networks may indicate node connectivity rather than the influence or potential causality among nodes. These results help to elucidate the relationship between PTSD and depression and could contribute to the development of appropriate therapies.
青少年创伤后应激障碍（PTSD）与抑郁症之间的高共病率通常发生在严重创伤事件之后。关于共病途径的模型存在很大争议，PTSD和抑郁症如何发生共病仍不清楚。
对424名九寨沟地震青少年幸存者进行了为期12个月（T1）和27个月（T2）的随访调查。
同期网络分析和交叉滞后面板网络分析表明，PTSD和抑郁症是两种独立的疾病，通过PTSD的烦躁症状与抑郁症的躯体或非躯体症状之间的联系存在强烈关联。然而，这种关联从T1到T2有所减弱，每种疾病内部症状之间的内在联系变得更强。
我们仅在地震后的两个时间点测量了PTSD和抑郁症的共病情况，这可能会限制我们研究结果在创伤后的长期适用性。
研究结果还表明，同期网络中的中心性可能表明节点连通性，而非节点之间的影响或潜在因果关系。这些结果有助于阐明PTSD与抑郁症之间的关系，并可能有助于开发适当的治疗方法。
