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中国老年人认知功能转变特征及影响因素:一项8年纵向研究。

Characteristics of the cognitive function transition and influencing factors among Chinese older people: An 8-year longitudinal study.

作者信息

Du Yurun, Hu Naifan, Yu Zhenfan, Liu Xiaojuan, Ma Yuzhuo, Li Jiangping

机构信息

Department of Epidemiology and Health Statistics, School of Public Health and Management, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, China.

Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.

出版信息

J Affect Disord. 2023 Mar 1;324:433-439. doi: 10.1016/j.jad.2022.12.116. Epub 2022 Dec 28.

Abstract

BACKGROUND

Cognitive impairment among older people is an important public health problem in developing countries. Therefore, it is necessary to identify the subtypes of cognitive function among older people in China, and explore the transformation patterns and influencing factors.

METHODS

Longitudinal data from the China Health and Retirement Longitudinal Study (CHARLS) were used, and included 2140 women and 2049 men aged over 60 years. Latent profile and latent transition analysis (LPA&LTA) were used to identify subgroups and transitions between the profiles over time. Influencing factors were identified by multinomial logistic regression analysis.

RESULTS

According to the LPA model, three subgroups of cognitive function were identified: Cognitive Impairment, Mild Cognitive Impairment (MCI) and Normal Cognitive Function. Concurrently, >50 % of participants were likely to progress to MCI after seven years, whereas participants with cognitive impairment had a probability of 54.2 % of transitioning to a better cognitive profile. Older adults are less likely to experience cognitive improvement, higher levels of education affect changes in cognition, and having depression are at a lower risk of cognitive decline.

LIMITATIONS

Due to the incompleteness of the cognitive assessment and the large time span, there was a certain bias in the classification and analysis of latent cognitive profiles.

CONCLUSION

This study identified three latent profiles among Chinese older people and showed the stability and heterogeneity. It demonstrated the effects of higher age or levels of education, and depression on changes in cognitive function in older people.

摘要

背景

老年人认知障碍是发展中国家一个重要的公共卫生问题。因此,有必要在中国老年人中识别认知功能的亚型,并探索其转变模式及影响因素。

方法

使用中国健康与养老追踪调查(CHARLS)的纵向数据,纳入2140名60岁以上女性和2049名60岁以上男性。采用潜在类别分析和潜在转变分析(LPA&LTA)来识别亚组以及随时间推移各类别之间的转变。通过多项逻辑回归分析确定影响因素。

结果

根据LPA模型,识别出认知功能的三个亚组:认知障碍、轻度认知障碍(MCI)和正常认知功能。同时,超过50%的参与者在7年后可能进展为MCI,而认知障碍参与者有54.2%的概率转变为更好的认知状态。老年人认知改善的可能性较小,较高的教育水平影响认知变化,患有抑郁症的人认知衰退风险较低。

局限性

由于认知评估的不完整性和时间跨度大,潜在认知状态的分类和分析存在一定偏差。

结论

本研究在中国老年人中识别出三种潜在状态,并显示出其稳定性和异质性。它证明了较高年龄、教育水平以及抑郁症对老年人认知功能变化的影响。

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