University of Southern California, Los Angeles, CA, USA.
Nat Struct Mol Biol. 2023 Jan;30(1):5-8. doi: 10.1038/s41594-022-00904-6.
New work on DNA polymerase λ highlights its remarkable flexibility. This fits with the generally adaptable nature of the DNA-repair process in which this enzyme is involved — nonhomologous end-joining — which allows this mechanism to handle diverse types of broken DNA ends in order to restore the duplex structure, albeit with a loss of information at the join.
新的 DNA 聚合酶 λ 研究强调了其显著的灵活性。这与该酶参与的 DNA 修复过程的一般适应性相吻合——非同源末端连接，这使得该机制能够处理各种类型的断裂 DNA 末端，以恢复双链结构，但在连接处会丢失信息。
