Quader Sabina, Tanabe Shihori, Cabral Horacio
Innovation Center of Nanomedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki, 210-0821, Japan.
Division of Risk Assessment, Center for Biological Safety and Research, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, 210-9501, Japan.
Adv Exp Med Biol. 2022;1393:141-156. doi: 10.1007/978-3-031-12974-2_7.
Tumor resistance and recurrence have been associated with the presence of cancer stem cells (CSCs) in tumors. The functions and survival of the CSCs have been associated with several intracellular and extracellular features. Particularly, the abnormal glycosylation of these signaling pathways and markers of CSCs have been correlated with maintaining survival, self-renewal and extravasation properties. Here, we highlight the importance of glycosylation in promoting the stemness character of CSCs and the current strategies for targeting abnormal glycosylation toward generating effective therapies against the CSC population.
肿瘤耐药性和复发与肿瘤中癌症干细胞（CSCs）的存在有关。CSCs的功能和存活与多种细胞内和细胞外特征相关。特别是，这些信号通路和CSCs标志物的异常糖基化与维持存活、自我更新和外渗特性相关。在此，我们强调糖基化在促进CSCs干性特征方面的重要性，以及目前针对异常糖基化以产生针对CSC群体的有效疗法的策略。
