Khan Thahomina, Cabral Horacio
Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.
Front Oncol. 2021 Apr 6;11:649338. doi: 10.3389/fonc.2021.649338. eCollection 2021.
Cancer stem cell (CSCs) are deemed as one of the main reasons of tumor relapse due to their resistance to standard therapies. Numerous intracellular signaling pathways along with extracellular features are crucial in regulating CSCs properties, such as heterogeneity, plasticity and differentiation. Aberrant glycosylation of these cellular signaling pathways and markers of CSCs have been directly correlated with maintaining survival, self-renewal and extravasation properties. In this review, we highlight the importance of glycosylation in promoting stemness character of CSCs, and present strategies for targeting abnormal glycosylation to eliminate the resistant CSC population.
癌症干细胞（CSCs）因其对标准疗法具有抗性，被认为是肿瘤复发的主要原因之一。众多细胞内信号通路以及细胞外特征在调节CSCs的特性（如异质性、可塑性和分化）方面至关重要。这些细胞信号通路和CSCs标志物的异常糖基化与维持生存、自我更新和外渗特性直接相关。在本综述中，我们强调了糖基化在促进CSCs干性特征方面的重要性，并提出了针对异常糖基化以消除耐药CSC群体的策略。
