Clinic of Small Animal Medicine, LMU University, Veterinaerstr. 13, 80539 Munich, Germany.
Clinic of Small Animal Medicine, LMU University, Veterinaerstr. 13, 80539 Munich, Germany.
J Vet Cardiol. 2023 Feb;45:3-14. doi: 10.1016/j.jvc.2022.11.002. Epub 2022 Dec 6.
Evaluation of two-dimensional speckle tracking (2D-ST)-derived global longitudinal strain (GLS) in healthy Doberman Pinschers (DP) is essential before it can be used in diseased DP to assess systolic function. To determine feasibility and observer related measurement variability of 2D-ST-derived GLS by use of AutoSTRAIN (AUTO) and 2D Cardiac Performance Analysis (TomTec Imaging Systems GmbH, Unterschleissheim, Germany).
ANIMALS, MATERIALS, AND METHODS: This prospective study included 120 healthy, client-owned DP presented for screening evaluation. Global longitudinal strain of the apical four- (GLS), two-, and three-chamber view as well as the average GLS of all three views combined (GLS) were determined, compared, and reference values established. Measurement variability was assessed by using intra- and inter-observer coefficient of variation.
A small difference existed for GLS (mean + 0.23%; P=0.022) between the two software programs although the determined strain values were similar and positively correlated (r = 0.84; P<0.001). No difference could be found between GLS and GLS for AUTO (mean + 0.16%; P=0.228), whereas a difference existed for Cardiac Performance Analysis (mean -0.89% (end-systolic strain) and -0.56% (peak strain), P<0.0001). Software specific reference values were established for GLS and GLS. Intra- and inter-observer coefficient of variation revealed very low to low measurement variability, with better results for AUTO.
Two-dimensional speckle tracking (2D-ST) derived GLS is a feasible technique to assess systolic function with low measurement variability. Whenever possible, GLS should be determined, although GLS might be a potential alternative.
在将二维斑点追踪（2D-ST）衍生的整体纵向应变（GLS）用于评估患病杜宾犬的收缩功能之前，评估健康杜宾犬的 2D-ST 衍生 GLS 至关重要。本研究旨在使用 AutoSTRAIN（AUTO）和 2D 心脏功能分析（TomTec Imaging Systems GmbH，德国）评估 2D-ST 衍生 GLS 的可行性和观察者间测量变异性。
动物、材料和方法：本前瞻性研究纳入了 120 只接受筛查的健康的、有主人的杜宾犬。确定并比较了心尖四腔（GLS）、两腔和三腔视图的整体纵向应变以及所有三个视图的平均 GLS（GLS），并建立了参考值。通过观察者内和观察者间的变异系数评估测量变异性。
两种软件程序的 GLS 存在微小差异（平均相差 0.23%，P=0.022），但测定的应变值相似且呈正相关（r=0.84，P<0.001）。AUTO 的 GLS 和 GLS 之间没有差异（平均相差 0.16%，P=0.228），而 Cardiac Performance Analysis 存在差异（收缩末期应变差为-0.89%，峰值应变差为-0.56%，P<0.0001）。为 GLS 和 GLS 建立了特定软件的参考值。观察者内和观察者间的变异系数显示出非常低至低的测量变异性，AUTO 的结果更好。
二维斑点追踪（2D-ST）衍生的 GLS 是一种评估收缩功能的可行技术，具有低测量变异性。只要可能，就应确定 GLS，尽管 GLS 可能是一种潜在的替代方法。
