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双侧放射性视网膜病变 17 年后:COVID-19 封锁期间放射治疗鼻咽癌后的诊断和治疗挑战。

Bilateral radiation retinopathy 17 years following radiotherapy for nasopharyngeal carcinoma: A diagnostic and therapeutic challenge during COVID-19 lockdown.

机构信息

Department of Ophthalmology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Vitreo-Retina Services, L. V. Prasad Eye Institute, Bhubaneswar, Odisha, India.

出版信息

Indian J Ophthalmol. 2023 Jan;71(1):303-305. doi: 10.4103/ijo.IJO_1526_22.

DOI:10.4103/ijo.IJO_1526_22
PMID:36588259
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10155549/
Abstract

A 40-year-old male presented with reduced vision in the right eye for one week. He had a history of nasopharyngeal carcinoma for which 34-Gy radiation was administered. The best-corrected visual acuity (BCVA) was 20/40 in the right eye and 20/20 in the left eye. Anterior segment examination suggested a bilateral early posterior subcapsular cataract. Fundoscopy revealed bilateral localized telangiectasia and macular edema in the right eye. Diagnosis of bilateral extremely delayed onset radiation retinopathy with right eye macular edema was made. Three doses of intravitreal bevacizumab injection were administered in the right eye. The patient was lost to follow-up due to COVID-19 and presented with recurrence.

摘要

一位 40 岁男性,因右眼视力下降一周就诊。他曾患有鼻咽癌,接受了 34Gy 的放射治疗。右眼最佳矫正视力(BCVA)为 20/40,左眼为 20/20。眼前节检查提示双眼早期后囊下白内障。眼底检查显示右眼双侧局限性毛细血管扩张和黄斑水肿。诊断为双眼极迟发性放射性视网膜病变伴右眼黄斑水肿。右眼玻璃体腔内注射了 3 剂贝伐单抗。由于 COVID-19 该患者失访并出现复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66cf/10155549/ec46219d84e9/IJO-71-303-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66cf/10155549/e45abe299fec/IJO-71-303-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66cf/10155549/48dd020f2f83/IJO-71-303-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66cf/10155549/904c18234918/IJO-71-303-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66cf/10155549/ec46219d84e9/IJO-71-303-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66cf/10155549/e45abe299fec/IJO-71-303-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66cf/10155549/48dd020f2f83/IJO-71-303-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66cf/10155549/904c18234918/IJO-71-303-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66cf/10155549/ec46219d84e9/IJO-71-303-g004.jpg

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本文引用的文献

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Delayed follow-up of medical retina patients due to COVID-19: impact on disease activity and visual acuity.由于 COVID-19 导致的医学视网膜患者随访延迟:对疾病活动和视力的影响。
Graefes Arch Clin Exp Ophthalmol. 2021 Jul;259(7):1773-1780. doi: 10.1007/s00417-021-05174-4. Epub 2021 May 11.
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Radiation retinopathy after external beam irradiation for nasopharyngeal carcinoma: A case report and review of the literature.鼻咽癌外照射后放射性视网膜病变:一例报告并文献复习
Pract Radiat Oncol. 2018 Nov-Dec;8(6):366-368. doi: 10.1016/j.prro.2018.03.010. Epub 2018 Apr 3.
3
Radiation Retinopathy 47 Years following Brachytherapy for Retinoblastoma.
视网膜母细胞瘤近距离放射治疗47年后的放射性视网膜病变
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Radiation therapy: posterior segment complications.放射治疗:后段并发症。
Dev Ophthalmol. 2013;52:114-23. doi: 10.1159/000351088. Epub 2013 Aug 26.
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Classification and treatment of radiation maculopathy.放射性黄斑病变的分类与治疗。
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Early macular morphological changes following plaque radiotherapy for uveal melanoma.葡萄膜黑色素瘤斑块放射治疗后的早期黄斑形态学变化
Retina. 2008 Feb;28(2):263-73. doi: 10.1097/IAE.0b013e31814b1b75.
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