月经周期中的普萘洛尔药代动力学。
Propranolol pharmacokinetics during the menstrual cycle.
作者信息
Abdu-Aguye I, Dunlop D, Patel P, Turner P
机构信息
Department of Clinical Pharmacology, St Bartholomew's Hospital, London, UK.
出版信息
Postgrad Med J. 1986 Dec;62(734):1093-5. doi: 10.1136/pgmj.62.734.1093.
Abstract
The pharmacokinetics of propranolol during menstruation and in the mid menstrual cycle have been studied in nine young women taking a single 80 mg tablet on each occasion. There were wide between-individual differences in the serum concentration at any given time (4-5 fold at peak concentrations) but the serum concentration time curves within individuals showed only mild variations. The differences between the average pharmacokinetic parameter estimates for the group did not differ significantly between the two periods of study.
摘要
在月经期间和月经周期中期，对9名年轻女性进行了研究，她们每次服用一片80毫克的普萘洛尔片剂。在任何给定时间，血清浓度存在较大的个体间差异（峰值浓度时为4至5倍），但个体内的血清浓度-时间曲线仅显示出轻微变化。该组平均药代动力学参数估计值在两个研究阶段之间没有显著差异。
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