Patel L G, Warrington S J, Pearson R M
Br Med J (Clin Res Ed). 1983 Oct 29;287(6401):1247-8. doi: 10.1136/bmj.287.6401.1247.
Six healthy women participated in a study of the concentrations of propranolol achieved in plasma after insertion of the drug into the vagina. In four of the women the concentrations were also determined after administration by mouth. The area under the concentration curve for propranolol administered per vaginam was significantly greater than that after oral administration. There were small significant reduction in systolic blood pressure, pulse rate, and forced expiratory volume in one second after vaginal administration but these did not cause any symptomatic side effects. The tolerability of the vagina to drugs and the safety of this form of treatment remain to be determined. Probably further studies of the contraceptive effects of propranolol should be conducted with the dextro isomer of the drug.
六名健康女性参与了一项关于将普萘洛尔插入阴道后血浆中所达到浓度的研究。其中四名女性在口服给药后也测定了浓度。经阴道给药的普萘洛尔浓度曲线下面积显著大于口服给药后的浓度曲线下面积。阴道给药后收缩压、脉搏率和一秒用力呼气量有小幅显著降低，但这些并未引起任何症状性副作用。阴道对药物的耐受性以及这种治疗方式的安全性仍有待确定。可能应该对普萘洛尔的右旋异构体的避孕效果进行进一步研究。
