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A proof-of-concept study poised to remodel the drug development process: Liver-Chip solutions for lead optimization and predictive toxicology.

作者信息

Nahle Zaher

机构信息

Center for Contemporary Sciences, Gaithersburg, Maryland, MD, United States.

出版信息

Front Med Technol. 2022 Dec 16;4:1053588. doi: 10.3389/fmedt.2022.1053588. eCollection 2022.

DOI:10.3389/fmedt.2022.1053588
PMID:36590153
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9800902/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec5c/9800902/d73b33094ef5/fmedt-04-1053588-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec5c/9800902/d73b33094ef5/fmedt-04-1053588-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec5c/9800902/d73b33094ef5/fmedt-04-1053588-g001.jpg

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本文引用的文献

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Commun Med (Lond). 2022 Dec 6;2(1):154. doi: 10.1038/s43856-022-00209-1.
2
US agency seeks to phase out animal testing.美国机构寻求逐步淘汰动物试验。
Nature. 2022 Nov 4. doi: 10.1038/d41586-022-03569-9.
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High-throughput 3D microvessel-on-a-chip model to study defective angiogenesis in systemic sclerosis.高通量 3D 微脉管芯片模型用于研究系统性硬化症中的血管生成缺陷。
Front Immunol. 2024 May 21;15:1373186. doi: 10.3389/fimmu.2024.1373186. eCollection 2024.
4
Organ chip research in Europe: players, initiatives, and policies.欧洲的器官芯片研究：参与者、倡议与政策
Front Bioeng Biotechnol. 2023 Sep 4;11:1237561. doi: 10.3389/fbioe.2023.1237561. eCollection 2023.
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Manufacturing the multiscale vascular hierarchy: progress toward solving the grand challenge of tissue engineering.制造多尺度血管层次结构：解决组织工程重大挑战的进展。
Trends Biotechnol. 2023 Nov;41(11):1400-1416. doi: 10.1016/j.tibtech.2023.04.003. Epub 2023 May 9.
Sci Rep. 2022 Oct 8;12(1):16930. doi: 10.1038/s41598-022-21468-x.
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Why 90% of clinical drug development fails and how to improve it?为什么90%的临床药物研发会失败以及如何改进？
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