Huerter Mary E, Hammadeh Rasheed, Zhou Quan, Weisberg Asher, Riker Adam I
Department of Surgery, University of Illinois at Chicago, Chicago, IL.
Department of Pathology, Advocate Cancer Institute, Advocate Christ Medical Center, Oak Lawn, IL.
Ochsner J. 2014 Summer;14(2):282-6.
Amyloidosis of the breast is an unusual diagnosis. Overall, only 2 major case series have been published in the literature since the time amyloidosis was first reported in 1973, highlighting the rare nature of this disease. Clinically, the patient may present with a breast mass or simply increased breast density and skin thickening. As such, amyloidosis may mimic the appearance of a number of pathologies, both benign and malignant.
We report a single case of a patient who presented with a breast mass and was ultimately diagnosed with primary amyloidosis of the breast. We also present a review of the literature to date.
The main treatment for primary amyloidosis of the breast is surgical removal, most often accomplished with breast conservation via lumpectomy. In performing the lumpectomy, the goal should be to obtain negative surgical margins; however, no strong data exist to suggest that such lesions would recur with a microscopically positive margin.
乳腺淀粉样变性是一种不常见的诊断。自1973年首次报道淀粉样变性以来，总体上仅有2个主要病例系列发表于文献中，凸显了这种疾病的罕见性。临床上，患者可能表现为乳腺肿块，或仅仅是乳腺密度增加和皮肤增厚。因此，淀粉样变性可能会模仿多种良性和恶性病变的表现。
我们报告了1例表现为乳腺肿块并最终被诊断为原发性乳腺淀粉样变性的患者。我们还对迄今为止的文献进行了综述。
原发性乳腺淀粉样变性的主要治疗方法是手术切除，最常通过肿块切除术进行保乳手术来完成。在进行肿块切除术时，目标应该是获得阴性手术切缘；然而，没有有力数据表明此类病变在显微镜下切缘阳性时会复发。
