Pavlica Matic, Kržan Mojca, Nemec Ana, Kosjek Tina, Baš Anže, Seliškar Alenka
Small Animal Clinic, Veterinary Faculty, University of Ljubljana, Ljubljana, Slovenia.
Department of Pharmacology and Experimental Toxicology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Front Vet Sci. 2022 Dec 14;9:1055231. doi: 10.3389/fvets.2022.1055231. eCollection 2022.
Data are lacking on the pharmacokinetic profile and safety of levobupivacaine (LB) used for regional anesthesia of the maxilla and mandibles in dogs.
Infraorbital block ( = 10), inferior alveolar block ( = 10) or both infraorbital and inferior alveolar blocks ( = 10) were administered to dogs undergoing dental surgery under isoflurane anesthesia. The dose of LB was calculated as 0.11 ml/kg for the infraorbital block and 0.18 ml/kg for the inferior alveolar block. Blood samples were collected before and immediately after administration of the oral blocks, and 3, 4, 7, 12, 17, 32, 47, 62, 92, and 122 min thereafter. Quantification of LB in plasma was performed by LC-MS/MS.
The results are presented as median and interquartile range. In dogs in which all four quadrants of the oral cavity were desensitized with LB, the was 1,335 (1,030-1,929) ng/ml, the was 7 (4-9.5) min, and the AUC was 57,976 (44,954-96,224) ng min/ml. Plasma concentrations of LB were several times lower than the reported toxic concentrations, and no signs of cardiovascular depression or neurotoxicity were observed in any of the dogs, suggesting that the occurrence of severe adverse effects after administration of LB at the doses used in this study is unlikely.
关于左旋布比卡因（LB）用于犬上颌和下颌区域麻醉的药代动力学特征及安全性的数据尚缺乏。
对在异氟烷麻醉下接受牙科手术的犬进行眶下阻滞（n = 10）、下牙槽阻滞（n = 10）或眶下和下牙槽联合阻滞（n = 10）。眶下阻滞的LB剂量计算为0.11 ml/kg，下牙槽阻滞为0.18 ml/kg。在口腔阻滞给药前、给药后即刻以及此后3、4、7、12、17、32、47、62、92和122分钟采集血样。通过液相色谱-串联质谱法对血浆中的LB进行定量。
结果以中位数和四分位数间距表示。在口腔四个象限均用LB脱敏的犬中，Cmax为1335（1030 - 1929）ng/ml，Tmax为7（4 - 9.5）分钟，AUC为57976（44954 - 96224）ng·min/ml。LB的血浆浓度比报道的中毒浓度低几倍，且在任何犬中均未观察到心血管抑制或神经毒性迹象，这表明在本研究使用的剂量下给予LB后不太可能发生严重不良反应。
