Corrigall W A
Neurobiology Section, Addiction Research Foundation, Toronto, Ontario, Canada.
Pharmacol Biochem Behav. 1987 Aug;27(4):693-700. doi: 10.1016/0091-3057(87)90196-1.
The involvement of the lateral hypothalamus and medial prefrontal cortex in mediating heroin self-administration was examined by means of intracranial microinjections of the quaternary opiate antagonist methyl naltrexone over a dose range of 0-3.0 micrograms. In animals trained to respond on a continuous reinforcement schedule for intravenous heroin (0.03 mg/kg/infusion), microinfusions of antagonist into the lateral hypothalamus prior to a self-administration session produced significant dose-related increases in responding on the drug manipulandum, similar to increases in responding observed after treatment with naltrexone systemically. Microinfusions of quaternary antagonist into the medial prefrontal cortex over the same dose range effective in the lateral hypothalamus did not produce response increases. These data suggest that opiate action in the lateral hypothalamus, but not in the medial prefrontal cortex, is salient in maintenance of intravenous self-administration.
通过在0 - 3.0微克剂量范围内颅内微量注射季铵类阿片拮抗剂甲基纳曲酮，研究了外侧下丘脑和内侧前额叶皮质在介导海洛因自我给药中的作用。在经过训练按连续强化程序对静脉注射海洛因（0.03毫克/千克/输注）做出反应的动物中，在自我给药前向外测下丘脑微量注射拮抗剂，导致在药物操作杆上的反应出现显著的剂量相关增加，类似于全身注射纳曲酮后观察到的反应增加。在与外侧下丘脑相同有效剂量范围内，向内侧前额叶皮质微量注射季铵类拮抗剂并未引起反应增加。这些数据表明，外侧下丘脑而非内侧前额叶皮质中的阿片作用，在维持静脉自我给药中很显著。
