Department of Integrative Bioscience and Biotechnology, College of Life Sciences, Sejong University, Seoul 05006, Korea.
BMB Rep. 2023 Apr;56(4):240-245. doi: 10.5483/BMBRep.2022-0205.
Glial cells play important roles during neurogenesis and in maintaining complex functions of the nervous system. Here, we report the characterization of a gene, Sdr, which contains a putative insulin-like growth factor receptor domain and is required to maintain critical nervous system functions in Drosophila. Sdr is expressed in glial cells during embryonic and larval stages of development, but its role in adult flies is poorly understood. As insulin signaling is important throughout the lifespan in human, we investigated the Sdr's role in adult flies. Our results demonstrate that Sdr is expressed on surface glial cells that surround the nervous system. Mutation of Sdr did not affect development but caused defects in locomotion and lifespan. Sdr mutants also showed increasingly severe defects in the bloodbrain- and blood-retina-barriers as they aged. Therefore, we suggest a novel role of Sdr in maintaining the integrity of the blood-brain- and blood-retina-barriers in adult flies. [BMB Reports 2023; 56(4): 240-245].
神经胶质细胞在神经发生和维持神经系统的复杂功能中发挥着重要作用。在这里，我们报告了一个基因 Sdr 的特征，该基因包含一个推定的胰岛素样生长因子受体结构域，在果蝇中需要维持关键的神经系统功能。Sdr 在胚胎和幼虫发育阶段在神经胶质细胞中表达，但在成年果蝇中的作用知之甚少。由于胰岛素信号在人类的整个生命周期中都很重要，我们研究了 Sdr 在成年果蝇中的作用。我们的结果表明，Sdr 表达在环绕神经系统的表面神经胶质细胞上。Sdr 的突变不会影响发育，但会导致运动和寿命缺陷。随着年龄的增长，Sdr 突变体在血脑和血视网膜屏障方面的缺陷也越来越严重。因此，我们建议 Sdr 在维持成年果蝇血脑和血视网膜屏障完整性方面具有新的作用。[BMB 报告 2023;56(4):240-245]。
