Hospital Moinhos de Vento, PROADI-SUS, Porto Alegre, Brazil.
Department of Microbiology and Ophthalmology, Harvard Medical School and Mass Eye and Ear Infirmary, Boston, USA.
Arch Virol. 2023 Jan 3;168(1):19. doi: 10.1007/s00705-022-05648-8.
Cases of reinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported worldwide. We investigated reinfection cases in a set of more than 30,000 samples, and the SARS-CoV-2 genomes from selected samples from four patients with at least two positive diagnoses with an interval ≥ 45 days between tests were sequenced and analyzed. Comparative genomic and phylogenetic analysis confirmed three reinfection cases and suggested that the fourth one was caused by a virus of the same lineage. Viral sequencing is crucial for understanding the natural course of reinfections and for planning public health strategies for management of COVID-19.
已在全球范围内报告了严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的再感染病例。我们对超过 30000 个样本的一组再感染病例进行了调查，并对至少两次阳性诊断、两次检测间隔≥45 天的四个患者的 SARS-CoV-2 基因组进行了测序和分析。比较基因组和系统发育分析证实了三例再感染病例，并提示第四例可能是由同一谱系的病毒引起的。病毒测序对于了解再感染的自然病程以及制定 COVID-19 管理的公共卫生策略至关重要。
