Wolfe J N, Buck K A, Salane M, Parekh N J
Department of Radiology, Hutzel Hospital, Detroit, MI 48201.
Radiology. 1987 Nov;165(2):305-11. doi: 10.1148/radiology.165.2.3659348.
Xeroradiography was performed on 21,057 new patients referred over a 5 1/2-year period. For purposes of analysis, mammograms reported as "benign" or "follow-up suggested" were considered negative and those reported as "suspicious" or "strongly suggestive of cancer" were considered positive. All patients were followed up for 12 months. After 6 months, 773 breast cancers were diagnosed. An additional 19 cancers were proved to exist during the 6-12-month period. The cancer rate increased progressively with age and ranged from 1.2% at age 30-39 years, to 4.5% at age 50-59 years, to 11.8% at age 70 years and over. Mammography had a sensitivity of 91.1%, a specificity of 89.9%, and a predictive value of 25.5%. Sensitivity increased with age, ranging from 78.5% at age 30-39 to 95.1% at age 70 and over. Predictive value increased dramatically with age, varying from 12.4% at age 30-39, to 28.4% at age 50-59, to 49.4% at age 70 years and over.
在5年半的时间里，对21057名新转诊患者进行了干板X线照相术。为了便于分析，报告为“良性”或“建议随访”的乳房X线照片被视为阴性，报告为“可疑”或“强烈提示癌症”的则被视为阳性。所有患者均接受了12个月的随访。6个月后，诊断出773例乳腺癌。在6至12个月期间又证实存在19例癌症。癌症发病率随年龄增长而逐渐升高，30至39岁年龄段为1.2%，50至59岁年龄段为4.5%，70岁及以上年龄段为11.8%。乳房X线照相术的敏感度为91.1%，特异度为89.9%，预测值为25.5%。敏感度随年龄增长而增加，30至39岁年龄段为78.5%，70岁及以上年龄段为95.1%。预测值随年龄显著增加，30至39岁年龄段为12.4%，50至59岁年龄段为28.4%，70岁及以上年龄段为49.4%。
