National Engineering Laboratory for Animal Breeding and Key Laboratory of Animal Genetics, Breeding and Reproduction, MARA, Beijing, China.
College of Animal Science and Technology, China Agricultural University, Beijing, China.
Anim Genet. 2023 Apr;54(2):211-215. doi: 10.1111/age.13289. Epub 2023 Jan 2.
Angel wing is a developmental wing deformity that can influence breeding and reproduction in the commercial duck industry. The nutrition foundation of angel wing trait was initially explored, but the genetic basic remains poorly understood. In this study, we identified candidate genes and single-nucleotide polymorphisms (SNPs) associated with angel wing trait in Pekin ducks using a genome-wide association study (GWAS) and selective sweep analysis. The GWAS results showed that nine SNPs across five chromosomes were significantly correlated with the angel wing trait. In total, 468 selection signals were shown between the angel wing ducks and normal ducks, and these signals harbored 154 genes, which were enriched in the nervous system and metabolism. This study provides the new insights into the genetic factors that may influence duck angel wing.
天使翅是一种发育性翅畸形，会影响商业鸭业的繁殖和生产。最初探索了天使翅性状的营养基础，但遗传基础仍知之甚少。在这项研究中，我们使用全基因组关联研究（GWAS）和选择清扫分析鉴定了与北京鸭天使翅性状相关的候选基因和单核苷酸多态性（SNP）。GWAS 结果表明，五个染色体上的九个 SNP 与天使翅性状显著相关。在天使翅鸭和正常鸭之间共检测到 468 个选择信号，这些信号包含 154 个基因，这些基因在神经系统和代谢中富集。本研究为影响鸭天使翅的遗传因素提供了新的见解。
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