Dore R, La Fianza A, Franchi M, Spinillo A, Cichero P, Biazzi L
Istituto di Radiologia, Università di Pavia.
Radiol Med. 1987 Sep;74(3):166-70.
A Quantitative Computed Tomography (QCT) method, simplifying the well-known technique proposed by Genant (1982) and applied to a standard third generation whole body CT scanner is described. This technique was applied in the measurement of the trabecular bone which has high sensitivity for metabolic changes. The BMC (Bone Mineral Content) measured in different groups of subjects (healthy postmenopausal patients versus women with postmenopausal osteoporosis) showed a highly significant difference (p less than 0.001). The precision of repositioning (coefficient of variation 1.8% to 2.3%, obtained in healthy male patients) and the good, linear relationship computed from the phantom values, minimize measurement errors. Since this method is quickly applied and involves low-dose radiation-exposure, it could be introduced in the clinical study of metabolic bone diseases.
描述了一种定量计算机断层扫描（QCT）方法，该方法简化了Genant（1982年）提出的著名技术，并应用于标准第三代全身CT扫描仪。该技术用于测量对代谢变化具有高敏感性的小梁骨。在不同组受试者（健康绝经后患者与绝经后骨质疏松症女性）中测量的骨矿物质含量（BMC）显示出高度显著差异（p小于0.001）。在健康男性患者中获得的重新定位精度（变异系数为1.8%至2.3%）以及根据体模值计算出的良好线性关系，将测量误差降至最低。由于该方法应用快速且辐射暴露剂量低，因此可引入代谢性骨病的临床研究。
