Department of Chemistry, University of York Heslington, York, YO10 5DD, UK.
Department of Chemistry, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
Chemistry. 2023 Mar 16;29(16):e202203807. doi: 10.1002/chem.202203807. Epub 2023 Feb 8.
A one-step method for the conversion of nitroarenes into phenols under operationally simple, transition-metal-free conditions is described. This denitrative functionalization protocol provides a concise and economical alternative to conventional three-step synthetic sequences. Experimental and computational studies suggest that nitroarenes may be substituted by an electron-catalysed radical-nucleophilic substitution (S 1) chain mechanism.
本文描述了一种在操作简单、无需过渡金属的条件下将硝基芳烃转化为酚类化合物的一步法。与传统的三步合成序列相比，这种脱硝化官能团化方法提供了一种简洁、经济的替代方案。实验和计算研究表明，硝基芳烃可能通过电子催化的自由基-亲核取代（S1）链机制进行取代。
